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Effects of Dietary Serine Supplementation on Intestinal Integrity, Inflammation and Oxidative Status in Early-Weaned Piglets

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成果类型:
期刊论文
作者:
Zhou, Xihong;Zhang, Yumei;Wu, Xin*;Wan, Dan;Yin, Yulong*
通讯作者:
Wu, Xin;Yin, Yulong
作者机构:
[Zhou, Xihong; Wu, Xin; Wan, Dan; Yin, Yulong; Zhang, Yumei] Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha, Hunan, Peoples R China.
[Zhou, Xihong; Wu, Xin; Wan, Dan; Yin, Yulong; Zhang, Yumei] Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha, Hunan, Peoples R China.
[Wu, Xin; Yin, Yulong; Zhang, Yumei] Hunan Agr Univ, Coll Anim Sci & Technol, CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Hunan, Peoples R China.
[Zhou, Xihong] China Agr Univ, State Key Lab Anim Nutr, Beijing, Peoples R China.
[Wu, Xin; Yin, YL] Chinese Acad Sci, Inst Subtrop Agr, CAS 644 Yuanda 2nd Rd, Changsha 410125, Hunan, Peoples R China.
通讯机构:
[Wu, X; Yin, YL] C
Chinese Acad Sci, Inst Subtrop Agr, CAS 644 Yuanda 2nd Rd, Changsha 410125, Hunan, Peoples R China.
语种:
英文
关键词:
Inflammation;Intestine integrity;Oxidative stress;Serine;Weaning
期刊:
Cellular Physiology and Biochemistry
ISSN:
1015-8987
年:
2018
卷:
48
期:
3
页码:
993-1002
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31702125, 31772642, 81273990]; National Key Research and Development Program of China [2018YFD0500405, 2016YFD0501201, 2016YFD0500504]; Agricultural Innovation Project of Hunan Province [2017YC03]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017113373]; earmarked fund for China Agriculture Research System [CARS-35]
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Background/Aims: Early weaning often causes gut dysfunction. Since serine alleviates oxidative stress and inflammatory response which are accompany with early weaning, we conducted the study to explore whether serine improves intestinal function in early-weaned piglets. Methods: Twenty-eight weaned piglets (aged 21 d) were fed either a basal diet or a basal diet plus 0.2% serine. We determined the effects of dietary serine supplementation on intestinal morphology by hematoxylin and eosin staining, expression of tight junction proteins (TJPs) by...

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