Functions of pregnane X receptor in self-detoxification

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成果类型：

期刊论文

作者：

He, Liuqin;Zhou, Xihong;Huang, Niu;Li, Huan;Li, Tiejun;...

通讯作者：

Yao, Kang;Yin, Yulong

作者机构：

[Zhou, Xihong; Yao, Kang; Yao, K; Yin, YL; Li, Tiejun; Yin, Yulong; He, Liuqin] Chinese Acad Sci, Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Key Lab Agroecol Proc Subtrop Reg,Minist Agr, Changsha 410125, Hunan, Peoples R China.

[He, Liuqin] Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China.

[Huang, Niu; Yao, Kang; Tian, Yanan; Li, Huan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Tian, Yanan] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA.

[Hu, Chien-An Andy] Univ New Mexico, Hlth Sci Ctr, Dept Biochem & Mol Biol, MSC08 4670, Albuquerque, NM 87131 USA.

通讯机构：

[Yao, K; Yin, YL] C

[Yao, Kang; Yao, K; Yin, YL] H

Chinese Acad Sci, Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Key Lab Agroecol Proc Subtrop Reg,Minist Agr, Changsha 410125, Hunan, Peoples R China.

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

CYP450;Inflammatory response;NF-kappaB;PXR;Self-detoxification

期刊：

Amino Acids

ISSN：

0939-4451

年：

2017

卷：

期：

页码：

1999-2007

DOI：

10.1007/s00726-017-2435-0

基金类别：

Hunan Outstanding Young Scholars Foundation [2016JJ1015]; National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127301, 2013CB127306]; National Natural Science Foundation ProjectNational Natural Science Foundation of China (NSFC) [31472107]; Chinese Academy of Sciences "Hundred Talent" award; Open Foundation of Key Laboratory of Agro-ecological Processes in Subtropical Region; Institute of Subtropical Agriculture, Chinese Academy of SciencesChinese Academy of Sciences [ISA2016101]; National Science and Technology Support Project [2013BAD21B04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472106]; Chinese Academy of SciencesChinese Academy of Sciences [2016VBB007]

机构署名：

本校为通讯机构

院系归属：

动物科学技术学院

摘要：

Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize...

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