Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro

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成果类型：

期刊论文

作者：

Liu, Ke;Feng, Xiuli;Ma, Zhiyong;Luo, Chao;Zhou, Bin;...

通讯作者：

Chen, Puyan

作者机构：

[Zhou, Bin; Pang, Ran; Chen, Puyan; Cao, Ruibing; Lian, Xue; Huang, Li; He, Danni; Liu, Ke; Feng, Xiuli] Nanjing Agr Univ, Dept Vet Med Coll, Key Lab Anim Dis Diagnost & Immunol, Nanjing 210095, Jiangsu, Peoples R China.

[Ma, Zhiyong] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China.

[Luo, Chao] Hunan Agr Univ, Dept Orient Sci & Technol Coll, Changsha, Hunan, Peoples R China.

[Miao, Denian] Shanghai Acad Agr Sci, Shanghai, Peoples R China.

[Chen, Puyan] Nanjing Agr Univ, Dept Vet Med Coll, Key Lab Anim Dis Diagnost & Immunol, YiFu 4037, Nanjing 210095, Jiangsu, Peoples R China.

通讯机构：

[Chen, Puyan] N

Nanjing Agr Univ, Dept Vet Med Coll, Key Lab Anim Dis Diagnost & Immunol, YiFu 4037, Nanjing 210095, Jiangsu, Peoples R China.

语种：

英文

关键词：

Porcine reproductive and respiratory syndrome virus;Phage display;Antiviral peptide

期刊：

Virology

ISSN：

0042-6822

年：

2012

卷：

432

期：

页码：

73-80

DOI：

10.1016/j.virol.2012.05.010

基金类别：

Shanghai Veterinary Research Institute; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

机构署名：

本校为其他机构

院系归属：

东方科技学院

摘要：

Porcine reproductive and respiratory syndrome is an important infectious disease of pigs and has a significant harmful effect on the livestock industry, especially in China. PRRSV ORF1b gene encodes primary proteins which play a vital role during PRRSV replication. In this paper, various 12-amino-acid peptides were displayed. These peptides could bind to the polymerase and helicase of PRRSV ORF1b protein, respectively, in which p9 exerted the highest antiviral activity with an IC50 of 56 mu M, and the minimum toxicity to cells. It was proved that p9 inhibited PRRSV replication in infected MARC...

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Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro

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