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Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis

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成果类型:
期刊论文
作者:
Tang, Xiaopeng;Liu, Bo;Wang, Xiangrong;Yu, Qifang;Fang, Rejun*
通讯作者:
Fang, Rejun
作者机构:
[Liu, Bo; Fang, Rejun; Yu, Qifang; Tang, Xiaopeng; Wang, Xiangrong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Fang, Rejun; Wang, Xiangrong] Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Fang, Rejun] H
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
antioxidant;apoptosis;epidermal growth factor;lipopolysaccharides (LPS);oxidative stress
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2018
卷:
19
期:
3
基金类别:
Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ2163]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572419]; Science and Technology Projects of Changsha City [kh1601185]; Hunan Graduate Student Research Innovation Project [CX2016B276]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
The epidermal growth factor (EGF) has been widely used for protection of stress-induced intestinal mucosa dysfunction. However, whether EGF would alleviate oxidative injury and reduce apoptosis in porcine intestine is not yet known. Therefore, the aim of this study was to investigate the effect of EGF on lipopolysaccharides (LPS)-induced induction of oxidative stress and ensuing apoptosis in the porcine intestinal epithelial cell line, IPEC-J2. The present study showed that EGF significantly increased cell viability and decreased the LPS-induced induction of apoptosis, dehydrogenase (LDH) rele...

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