Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Funaro, Antonietta;Wu, Xian;Song, Mingyue;Zheng, Jinkai;Guo, Shanshan;...

通讯作者：

Xiao, Hang

作者机构：

[Wu, Xian; Zheng, Jinkai; Xiao, Hang; Rakariyatham, Kanyasiri; Guo, Shanshan; Song, Mingyue; Funaro, Antonietta] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

[Rodriguez-Estrada, Maria Teresa; Funaro, Antonietta] Univ Bologna, Dept Agr & Food Sci, Alma Mater Studiorum, Bologna, Italy.

[Xiao, Hang] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China.

[Zheng, Jinkai] Chinese Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Beijing 100193, Peoples R China.

[Guo, Shanshan] Univ Jinan, Dept Food Sci & Nutr, Sch Business, Jinan, Shandong, Peoples R China.

通讯机构：

[Xiao, Hang] U

Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

语种：

英文

关键词：

COX-2;inflammation;iNOS;luteolin;nitric oxide;synergy;tangeretin

期刊：

Journal of Food Science

ISSN：

0022-1147

年：

2016

卷：

期：

页码：

H1320-H1327

DOI：

10.1111/1750-3841.13300

基金类别：

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA139174]; AICR; USDAUnited States Department of Agriculture (USDA); Univ. of Jinan [XBS1350]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Dietary components in combination may act synergistically and produce enhanced biological activities. Herein, we investigated the anti‐inflammatory effects of 2 flavonoids, that is luteolin (LUT) and tangeretin (TAN) in combination. Lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophages were treated with noncytotoxic concentrations of LUT, TAN, and their combinations. The results showed that LUT/TAN in combination produced synergistic inhibitory effects on LPS‐stimulated production of nitric oxide (NO). ELISA results demonstrated that LUT...

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Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin

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