Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells

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成果类型：

期刊论文

作者：

Jiang, Qian;He, Liuqin;Hou, Yongqing;Chen, Jiashun;Duan, Yehui;...

通讯作者：

Yao, Kang

作者机构：

[Chen, Jiashun; Yao, Kang; Duan, Yehui; Wu, Guoyao; Yin, Yulong; Jiang, Qian; He, Liuqin; Deng, Dun] Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Engn Res Ctr Healthy Livestock,Minist, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Changsha 410125, Hunan, Peoples R China.

[Duan, Yehui; Jiang, Qian; He, Liuqin] Univ Chinese Acad Sci, Beijing 10008, Peoples R China.

[Hou, Yongqing; Wu, Guoyao] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Chen, Jiashun; Yin, Yulong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410125, Hunan, Peoples R China.

[Deng, Dun] TRS Grp, Zhuzhou 412000, Peoples R China.

通讯机构：

[Yao, Kang] C

Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Engn Res Ctr Healthy Livestock,Minist, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Changsha 410125, Hunan, Peoples R China.

CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Alpha-ketoglutarate;PMECs;ERS;mTOR;Lactation

期刊：

Amino Acids

ISSN：

0939-4451

年：

2016

卷：

期：

页码：

2179-2188

DOI：

10.1007/s00726-016-2249-5

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127306]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472107]; Chinese Academy of Sciences through its Hundred Talent ProgramChinese Academy of Sciences; Hubei Hundred Talent program; Texas A&M AgriLife Research [H-8200]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Alpha-ketoglutarate (AKG), a key intermediate in the Krebs cycle, has been reported to promote protein synthesis through activating mechanistic targeting of rapamycin (mTOR) in enterocytes. The study tested the hypothesis that AKG may enhance growth and milk protein synthesis in porcine mammary epithelial cells (PMECs). PMECs were cultured for 96 h in Dulbecco’s modified Eagle’s-F12 Ham medium (DMEM-F12) containing prolactin (2 µg/ml) and AKG (0 or 1.5 mM). At the end of 96-h culture, the abundance of apoptosis-related proteins (caspase-3, c...

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Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells

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