It is difficult to directly determine mancozeb because they are insoluble in general solvents. And the residue analysis in agricultural and crops is more complicated currently. In this study, a rapid method has been developed for the determination of germicide mancozeb residues in apple. The mancozeb of apple sample, which was methylated by dimethyl sulfate, was extracted by the Quick, easy, cheap, effective, rugged and safe method and detected by ultra performance liquid chromatography-mass spectrometry under multiple reaction monitoring mode, then quantified by matrix-match standard solution...