期刊论文

Chan, Raymond C. K.

英文

Neuropsychology

0894-4105

2016

30

6

685-696

10.1037/neu0000284

"Strategic Priority Research Program (B)" of the Chinese Academy of Sciences [XDB02030002]; National Science Fund China [81088001, 91132701, 81571317, 31100747]; Beijing Training Project for the Leading Talents in S T [Z151100000315020]; Key Laboratory of Mental Health, Institute of Psychology

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Unwillingness to expend more effort to pursue high value rewards has been associated with motivational anhedonia in schizophrenia (SCZ) and abnormal dopamine activity in the nucleus accumbens (NAcc). The authors hypothesized that dysfunction of the NAcc and the associated forebrain regions are involved in the impaired effort expenditure decision-making of SCZ. Method: A 2 (reward magnitude: low vs. high) × 3 (probability: 20% vs. 50% vs. 80%) event-related fMRI design in the effort-expenditure for reward task (EEfRT) was used to examine the ne...