期刊论文

中文

食品科学

1002-6630

2003

24

1

121-124

10.3321/j.issn:1002-6630.2003.01.033

湖南省科技厅科研项目

本校为其他机构

本试验通过研究儿茶素对一氧化氮表达的影响来探讨儿茶素对肾病综合征的部分治疗机制.试验将30只SD.雌性大鼠随机分成对照组、肾病组、激素治疗组、儿茶素预防组、儿茶素治疗组、儿茶素+激素联合治疗组共六组,测定了24h尿蛋白排泄量,尿、血浆及肾局部中NO的浓度,并应用半定量评分法对各组大鼠病理改变进行计量分析.试验结果表明:儿茶素和激素均能减轻肾脏损害,且两者有协同治疗作用.儿茶素可能是通过上调肾局部及血浆中NO的含量,降低肾病大鼠24h尿蛋白的排泄,以延缓肾脏病理慢性进展.

It was to elucidate parts of possible mechanismof catechin in the rapeutic nephritic syndrome and to preventchronic renalprogressive i njury by investgating catechin effe ct onnitric oxide(NO)contentinplasma and renal cortex in this experiment.30f emale SDrats were randomly divided i nto six groups as control,nephritic,dexamethasone -treated,catechin -prevented,catechin -treated and dexamethasone associated catechin -tredted.Intheendofexperiment,th eexcretionof 24hurinaryprotein,a ndthenitricoxied(NO)concentrationsin plasmaandrenalcortexbymeans ofbi ochemistryassay were tested.Asemi quantitati...