AMPK/alpha-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs

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成果类型：

期刊论文

作者：

He, Liuqin;Huang, Niu;Li, Huan;Tian, Junquan;Zhou, Xihong;...

通讯作者：

Yao, Kang;Yin, Yulong

作者机构：

[Zhou, Xihong; Yao, Kang; Yao, K; Yin, YL; Li, Tiejun; Yin, Yulong; He, Liuqin; Tian, Junquan] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Processes Subtrop Reg, Beijing 100864, Peoples R China.

[Zhou, Xihong; Yao, Kang; Yao, K; Yin, YL; Li, Tiejun; Yin, Yulong; He, Liuqin; Tian, Junquan] Minist Agr, Hunan Prov Engn Res Ctr Healthy Livestock & Poult, Anim Nutr & Feed Sci South Cent, Sci Observing & Expt Stn, Changsha 410125, Hunan, Peoples R China.

[He, Liuqin; Tian, Junquan] Univ Chinese Acad Sci, Beijing 10008, Peoples R China.

[Huang, Niu; Yao, Kang; Li, Huan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Huang, Niu; He, Liuqin] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

通讯机构：

[Yao, K; Yin, YL] C

[Yao, K; Yin, YL] M

[Yao, Kang] H

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Processes Subtrop Reg, Beijing 100864, Peoples R China.

Minist Agr, Hunan Prov Engn Res Ctr Healthy Livestock & Poult, Anim Nutr & Feed Sci South Cent, Sci Observing & Expt Stn, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

aquaporins;ion transporters;alpha-ketoglutarate;AMPK;diarrhea

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2017

卷：

期：

页码：

2287-2298

DOI：

10.1021/acs.jafc.7b00324

基金类别：

National Natural Science Foundation ProjectNational Natural Science Foundation of China (NSFC) [31472107]; Hunan Outstanding Young Scholars Foundation [2016B1015]; Chinese Academy of Sciences "Hundred Talent" award; Open Foundation of Key Laboratory of Agro-ecological Processes in Subtropical Region; Institute of Subtropical AgricultureChinese Academy of Sciences; Chinese Academy of SciencesChinese Academy of Sciences [ISA2016101]; National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127301]; National Science and Technology Support Project [2013BAD21B04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472106]

机构署名：

本校为通讯机构

院系归属：

动物科学技术学院

摘要：

Water and ion absorption via sensitive aquaporins (AQPs) and ion channels is of critical importance in intestinal health. However, whether α-ketoglutarate (AKG) could improve intestinal water and ion homeostasis in lipopolysaccharide (LPS)-challenged piglets and whether the AMP-activated protein kinase (AMPK) pathway is involved remains largely unknown. This study was conducted to investigate the effect of dietary AKG supplementation on the small intestinal water and ion homeostasis through modulating the AMPK pathway in a piglet diarrhea model. A total of 32 weaned piglets were used in ...

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AMPK/alpha-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs

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