Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice

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成果类型：

期刊论文

作者：

Yin, Jie;Li, Yuying;Han, Hui;Chen, Shuai;Gao, Jing;...

通讯作者：

Wu, Xin;Li, Tiejun;Ren, Wenkai

作者机构：

[Liu, Gang; Chen, Shuai; Wu, X; Li, Tiejun; Wu, Xin; Yin, Yulong; Han, Hui; Yin, Jie; Li, Yuying; Gao, Jing] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China.

[Liu, Gang; Chen, Shuai; Wu, Xin; Li, Tiejun; Yin, Yulong; Han, Hui; Yin, Jie; Li, Yuying; Gao, Jing] Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Changsha, Hunan, Peoples R China.

[Deng, Jinping; Yin, Yulong; Yin, Jie; Ren, Wenkai] South China Agr Univ, Coll Anim Sci, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.

[Chen, Shuai; Han, Hui; Yin, Jie; Li, Yuying; Gao, Jing] Univ Chinese Acad Sci, Beijing, Peoples R China.

[Yu, Qifang; Huang, Xingguo; Fang, Rejun] Hunan Agr Univ, Dept Anim Sci, Changsha, Hunan, Peoples R China.

通讯机构：

[Wu, X; Li, TJ] C

[Ren, Wenkai] S

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China.

South China Agr Univ, Coll Anim Sci, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

acetic acid;gut microbiota;lipid metabolism;melatonin;microbiota transplantation

期刊：

Journal of Pineal Research

ISSN：

0742-3098

年：

2018

卷：

期：

页码：

e12524-

DOI：

10.1111/jpi.12524

基金类别：

National Key Research and Development Program [2016YFD0501200, 2016YFD0500500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472106, 31772617, 31872365, 31790411]; Chinese Academy of SciencesChinese Academy of Sciences [QYZDY-SSWSMC008]; Hunan Key Research Program [2017NK2320]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbi...

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Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice

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