Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes

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成果类型：

期刊论文

作者：

Zhou, Xihong;He, Liuqin;Zuo, Shengnan;Zhang, Yumei;Wan, Dan;...

通讯作者：

Wu, Xin;Liu, Gang;Wu, Canrong

作者机构：

[Zhou, Xihong; Huang, Pan; Liu, Gang; Long, Ciming; Wu, X; Liu, G; Wan, Dan; Wu, Xin; Yin, Yulong; He, Liuqin] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Beijing, Peoples R China.

[Zuo, Shengnan; Wu, Canrong] Hunan Univ TCM, Dept Pathogen & Immunol, Changsha 410007, Hunan, Peoples R China.

[Zuo, Shengnan] Hunan Guangxiu Hosp, Clin Lab Dept, Changsha 410000, Hunan, Peoples R China.

[Zhang, Yumei] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Coinnovat Ctr Anim Prod Safety, CICAPS, Changsha 410128, Hunan, Peoples R China.

[Zhou, Xihong] China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.

通讯机构：

[Wu, X; Liu, G] C

[Wu, Canrong] H

Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Beijing, Peoples R China.

Hunan Univ TCM, Dept Pathogen & Immunol, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

AMP-activated protein kinase;Glutathione;Hypermethylation;Oxidative stress;Serine;Steatosis

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ISSN：

0925-4439

年：

2018

卷：

1864

期：

页码：

488-498

DOI：

10.1016/j.bbadis.2017.11.009

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31702125, 31772642, 81273990]; National Key Research and Development Program of China [2016YFD0501201, 2016YFD0500504]; Major Project of Hunan Province [2015NK1002]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017113373]; earmarked fund for China Agriculture Research System [CARS-35]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Serine deficiency has been observed in patients with nonalcoholic fatty liver disease (NAFLD). Whether serine supplementation has any beneficial effects on the prevention of NAFLD remains unknown. The present study was conducted to investigate the effects of serine supplementation on hepatic oxidative stress and steatosis and its related mechanisms. Forty male C57BL/6J mice (9 week-old) were randomly assigned into four groups (n = 10) and fed: i) a low-fat diet; ii) a low-fat diet supplemented with 1% (wt:vol) serine; iii) a high-fat (HF) diet;...

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Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes

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