期刊论文

Li, Hongliang;Chen, Man-Hua

英文

Journal of Hepatology

0168-8278

2016

64

6

1365-1377

10.1016/j.jhep.2016.02.002

To determine the relevance of TRAF1 in hepatic metabolism, we first measured its expression levels in liver biopsy samples from normal donors and NAFLD patients. As shown in Fig. 1A, robustly enhanced expression of TRAF1 was observed in NAFLD patients compared with normal donors. Immunofluorescence experiments also revealed the increased expression of TRAF1 in the livers of NAFLD patients (Fig. 1B). To specify whether this increase occurs in hepatocytes, primary cells were isolated from wild

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Background & Aims Tumor necrosis factor receptor-associated factor 1 (TRAF1) is an important adapter protein that is largely implicated in molecular events regulating immunity/inflammation and cell death. Although inflammation is closely related to and forms a vicious circle with insulin dysfunction and hepatic lipid accumulation, the role of TRAF1 in hepatic steatosis and the related metabolic disorders remains unclear. Methods The participation of TRAF1 in the initiation and progression of hepatic steatosis was evaluated in high fat diet (HFD...