Dynamic expression of genes encoding subunits of inward rectifier potassium (Kir) channels in the yellow fever mosquito Aedes aegypti

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成果类型：

期刊论文

作者：

Yang, Zhongxia;Statler, Bethanie-Michelle;Calkins, Travis L.;Alfaro, Edna;Esquivel, Carlos J.;...

通讯作者：

Piermarini, Peter M.

作者机构：

[Yang, Zhongxia] Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Dis & Pes, Coll Plant Protect, Changsha, Hunan, Peoples R China.

[Rouhier, Matthew F.; Alfaro, Edna; Piermarini, Peter M.; Calkins, Travis L.; Statler, Bethanie-Michelle; Yang, Zhongxia; Esquivel, Carlos J.] Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Entomol, 224 Thorne Hall, Wooster, OH 44691 USA.

[Rouhier, Matthew F.] Kenyon Coll, Dept Chem, Gambier, OH 43022 USA.

[Denton, Jerod S.] Vanderbilt Univ, Med Ctr, Dept Anesthesiol, Nashville, TN USA.

[Denton, Jerod S.] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.

通讯机构：

[Piermarini, Peter M.] O

Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Entomol, 224 Thorne Hall, Wooster, OH 44691 USA.

语种：

英文

关键词：

Potassium channel;Aedes aegypti;Developmental expression;Blood feeding;Anal papillae;Malpighian tubules;Midgut;Ovaries

期刊：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

ISSN：

1096-4959

年：

2017

卷：

204

页码：

35-44

DOI：

10.1016/j.cbpb.2016.11.003

基金类别：

We thank Ms. Nuris Acosta (The Ohio State University) for technical assistance. The research was funded by grants to P.M. Piermarini from the Foundation for the National Institutes of Health through the Vector-Based Transmission of Control: Discovery Research (VCTR) program of the Grand Challenges in Global Health initiative ( PIER11VCTR ), and the Mosquito Research Foundation (2014-03). The contributions of Ms. Statler were supported by The Ohio State University Summer Research Opportunities Program.

机构署名：

本校为第一机构

院系归属：

植物保护学院

摘要：

Inward rectifier potassium (Kir) channels play fundamental roles in neuromuscular, epithelial, and endocrine function in mammals. Recent research in insects suggests that Kir channels play critical roles in the development, immune function, and excretory physiology of fruit flies and/or mosquitoes. Moreover, our group has demonstrated that mosquito Kir channels may serve as valuable targets for the development of novel insecticides. Here we characterize the molecular expression of 5 mRNAs encoding Kir channel subunits in the yellow fever mosquito, Aedes aegypti: Kin, Kir2A-c, Kir2B, Kir2B', an...

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Dynamic expression of genes encoding subunits of inward rectifier potassium (Kir) channels in the yellow fever mosquito Aedes aegypti

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