作者： Li, Wei;Deng, Yiwen;Ning, Yuese;He, Zuhua*;Wang, Guo-Liang

期刊： ANNUAL REVIEW OF PLANT BIOLOGY,2020年71:575-603 ISSN：1543-5008

通讯作者： He, Zuhua

作者机构： [Wang, Guo-Liang; Li, Wei; Ning, Yuese] Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China.;[Li, Wei] Hunan Agr Univ, Coll Plant Protect, Hunan Prov Key Lab Biol & Control Plant Dis & In, Changsha 410128, Peoples R China.;[He, Zuhua; Deng, Yiwen] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai 200032, Peoples R China.;[Wang, Guo-Liang] Ohio State Univ, Dept Plant Pathol, Columbus, OH 43210 USA.

通讯机构： [He, Zuhua] C;Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai 200032, Peoples R China.

关键词： broad-spectrum resistance;pattern recognition receptor;nucleotide-binding and leucine-rich repeat receptor;NLR;QTL;susceptibility gene;durable resistance;plant immunity;molecular breeding

摘要： Plant diseases reduce crop yields and threaten global food security, making the selection of disease-resistant cultivars a major goal of crop breeding. Broad-spectrum resistance (BSR) is a desirable trait because it confers resistance against more than one pathogen species or against the majority of races or strains of the same pathogen. Many BSR genes have been cloned in plants and have been found to encode pattern recognition receptors, nucleotide-binding and leucine-rich repeat receptors, and defense-signaling and pathogenesis-related proteins. In addition, the BSR genes that underlie quantitative trait loci, loss of susceptibility and nonhost resistance have been characterized. Here, we comprehensively review the advances made in the identification and characterization of BSR genes in various species and examine their application in crop breeding. We also discuss the challenges and their solutions for the use of BSR genes in the breeding of disease-resistant crops.

语种： 英文

作者： Zhang, Zhang*;Zhao, Wenming*;Xiao, Jingfa*;Bao, Yiming*;He, Shunmin*;...

期刊： Nucleic Acids Research,2020年48(D1):D24-D33 ISSN：0305-1048

通讯作者： Zhang, Zhang;Zhao, Wenming;Xiao, Jingfa;Bao, Yiming;He, Shunmin;Zhang, Guoqing;Li, Yixue;Zhao, Guoping;Chen, Runsheng

作者机构： [Zhang, Sisi; Sun, Mingyuan; Cao, Jiabao; Wang, Yanqing; Li, Zhao; Lan, Li; Li, Qianpeng; Lu, Mingming; Zhang, Zhang; Wang, Zhonghuang; Yuan, Na; Niu, Guangyi; Zhang, Xin; Bao, Yiming; Hao, Lili; Zhang, Hao; Shang, Yunfei; Zhang, Yadong; Du, Qiang; Zou, Dong; Chen, Huanxin; Zhang, Guoqing; Chen, Meili; Li, Rujiao; Teng, Xufei; Li, Yixue; Zhao, Wenming; Zhou, Qing; Gong, Zheng; Li, Zhaohua; Pan, Mengyu; Chen, Tingting; Duan, Guangya; Qian, Qiheng; Yu, Lei; Liu, Lin; Ma, Yingke; Wang, Qi; Wang, Pei; Yang, Fei; Dong, Lili; Zhang, Yuansheng; Kang, Hailong; Ying, Cui; Zhang, Zhewen; Xiao, JF; Bao, YM; He, SM; Zhao, Guoping; Chen, Runsheng; Du, Zhenglin; Sun, Yubin; Chen, Xu; Zeng, Jingyao; Zhu, Junwen; Zhu, Tongtong; Xiong, Zhuang; Wu, Song; Zhu, Junwei; Jiang, Meiye; Li, Mengwei; Xiao, Jingfa; Kang, Hongen; He, Shunmin; Liu, Xiaonan; Zhang, Yang; Sang, Jian; Tian, Dongmei; Li, Cuiping; Wang, Jinyue; Ma, Lina; Shi, Shuo; Song, Shuhui; Zhai, Shuang; Gao, Qianwen; Tang, Bixia] Natl Genom Data Ctr, Beijing 100101, Peoples R China.;[Zhang, Sisi; Sun, Mingyuan; Cao, Jiabao; Wang, Yanqing; Li, Zhao; Lan, Li; Li, Qianpeng; Lu, Mingming; Zhang, Zhang; Wang, Zhonghuang; Yuan, Na; Niu, Guangyi; Zhang, Xin; Bao, Yiming; Hao, Lili; Zhang, Hao; Shang, Yunfei; Zhang, Yadong; Du, Qiang; Zou, Dong; Chen, Huanxin; Chen, Meili; Li, Rujiao; Teng, Xufei; Zhao, Wenming; Zhou, Qing; Gong, Zheng; Zhang, Zhewen; Xiao, JF; Bao, YM; Li, Zhaohua; Pan, Mengyu; Chen, Tingting; Duan, Guangya; Qian, Qiheng; Yu, Lei; Liu, Lin; Ma, Yingke; Wang, Qi; Wang, Pei; Yang, Fei; Dong, Lili; Zhang, Yuansheng; Kang, Hailong; Ying, Cui; Du, Zhenglin; Sun, Yubin; Chen, Xu; Zeng, Jingyao; Zhu, Junwen; Zhu, Tongtong; Xiong, Zhuang; Wu, Song; Zhu, Junwei; Jiang, Meiye; Li, Mengwei; Xiao, Jingfa; Kang, Hongen; Liu, Xiaonan; Zhang, Yang; Sang, Jian; Tian, Dongmei; Li, Cuiping; Wang, Jinyue; Ma, Lina; Shi, Shuo; Song, Shuhui; Zhai, Shuang; Gao, Qianwen; Tang, Bixia] Chinese Acad Sci, BIG Data Ctr, Beijing Inst Genom, Beijing 100101, Peoples R China.;[Cao, Jiabao; Li, Zhao; Li, Qianpeng; Lu, Mingming; Zhang, Zhang; Niu, Guangyi; Bao, Yiming; Hao, Lili; Zhang, Hao; Shang, Yunfei; Zhang, Yadong; Du, Qiang; Zou, Dong; Chen, Meili; Li, Rujiao; Teng, Xufei; Zhao, Wenming; Gong, Zheng; Zhang, Zhewen; Xiao, JF; Bao, YM; Li, Zhaohua; Qian, Qiheng; Liu, Lin; Ma, Yingke; Wang, Qi; Wang, Pei; Yang, Fei; Zhang, Yuansheng; Zeng, Jingyao; Zhu, Tongtong; Xiong, Zhuang; Wu, Song; Jiang, Meiye; Li, Mengwei; Xiao, Jingfa; Liu, Xiaonan; Zhang, Yang; Sang, Jian; Wang, Jinyue; Ma, Lina; Shi, Shuo; Song, Shuhui; Gao, Qianwen] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China.;[He, SM; Chen, Runsheng; Zhang, Peng; Zheng, Yu; Niu, Yiwei; Kang, Quan; Xue, Hua; Zhang, Lili; Wang, Jiajia; He, Shunmin; Li, Yanyan; Teng, Yiheng; Chen, Xiaomin; Sun, Xianhui; Teng, Xueyi; Hao, Yajing] Chinese Acad Sci, Ctr Big Data Res Hlth, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China.;[Liu, Wan; Zhang, Chao; Lu, Yan; Zhang, Guoqing; Li, Yixue; Lv, Daqing; Gao, Yang; Zhao, Guoping; Xu, Shuhua; Ling, Yunchao; Cao, Ruifang; Yuan, Liyun; Ning, Zhilin] Chinese Acad Sci, Biomed Big Data Ctr, CAS MPG Partner Inst Computat Biol, Shanghai Inst Nutr & Hlth,Key Lab Computat Biol, Shanghai 200231, Peoples R China.

通讯机构： [Zhang, Z; Zhao, WM; Xiao, JF; Bao, YM; He, SM; Zhang, GQ; Li, YX; Zhao, GP; Chen, RS] N;[Zhang, Z; Zhao, WM; Xiao, JF; Bao, YM; He, SM; Chen, RS; Zhang, GQ; Li, YX; Zhao, GP; Zhao, Guoping] C;[Zhang, Z; Zhao, WM; Xiao, JF; Bao, YM; He, SM; Chen, RS] U;Natl Genom Data Ctr, Beijing 100101, Peoples R China.;Chinese Acad Sci, BIG Data Ctr, Beijing Inst Genom, Beijing 100101, Peoples R China.

摘要： The National Genomics Data Center (NGDC) provides a suite of database resources to support worldwide research activities in both academia and industry. With the rapid advancements in higher-throughput and lower-cost sequencing technologies and accordingly the huge volume of multi-omics data generated at exponential scales and rates, NGDC is continually expanding, updating and enriching its core database resources through big data integration and value-added curation. In the past year, efforts for update have been mainly devoted to BioProject, BioSample, GSA, GWH, GVM, NONCODE, LncBook, EWAS Atlas and IC4R. Newly released resources include three human genome databases (PGG.SNV, PGG.Han and CGVD), eLMSG, EWAS Data Hub, GWAS Atlas, iSheep and PADS Arsenal. In addition, four web services, namely, eGPS Cloud, BIG Search, BIG Submission and BIG SSO, have been significantly improved and enhanced. All of these resources along with their services are publicly accessible at https://bigd.big.ac.cn. © 2019 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.

语种： 英文

作者： Xiao, Chuan-Le;Zhu, Song;He, Minghui;Chen, De;Zhang, Qian;...

期刊： Molecular Cell,2018年71(2):306-318.e7 ISSN：1097-2765

通讯作者： Yan, Guang-Rong;Gu, Xiao-Feng;Bo, Xiao-Chen;Wang, Kai

作者机构： [Zhu, Song; Chen, De; Xiao, Chuan-Le; Yan, Guang-Rong] Guangzhou Med Univ, Affiliated Hosp 3, Biomed Res Ctr, Guangzhou 510150, Guangdong, Peoples R China.;[Xie, Shang-Qian; Chen, Ying; Xiao, Chuan-Le] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China.;[Xiao, Chuan-Le] Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China.;[Liu, Jinbao; Zhu, Song; Chen, De; Yan, Guang-Rong] Guangzhou Med Univ, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou 511436, Guangdong, Peoples R China.;[He, Minghui] CookGene Biosci Ctr, Guangzhou 510320, Guangdong, Peoples R China.

通讯机构： [Yan, Guang-Rong] G;[Gu, Xiao-Feng; Wang, Kai] C;[Bo, Xiao-Chen] B;Guangzhou Med Univ, Affiliated Hosp 3, Biomed Res Ctr, Guangzhou 510150, Guangdong, Peoples R China.;Guangzhou Med Univ, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou 511436, Guangdong, Peoples R China.

关键词： 6mA;cancer;demethylase;human genome;m6A;methylation;methyltransferase

摘要： DNA N 6 -methyladenine (6mA) modification is the most prevalent DNA modification in prokaryotes, but whether it exists in human cells and whether it plays a role in human diseases remain enigmatic. Here, we showed that 6mA is extensively present in the human genome, and we cataloged 881,240 6mA sites accounting for ∼0.051% of the total adenines. [G/C]AGG[C/T] was the most significantly associated motif with 6mA modification. 6mA sites were enriched in the coding regions and mark actively transcribed genes in human cells. DNA 6mA and N 6 -demethyladenine modification in the human genome were mediated by methyltransferase N6AMT1 and demethylase ALKBH1, respectively. The abundance of 6mA was significantly lower in cancers, accompanied by decreased N6AMT1 and increased ALKBH1 levels, and downregulation of 6mA modification levels promoted tumorigenesis. Collectively, our results demonstrate that DNA 6mA modification is extensively present in human cells and the decrease of genomic DNA 6mA promotes human tumorigenesis. Xiao et al. show that DNA methylation on N 6 -adenine exists in the human genome. The mark is added by the methyltransferase N6AMT1 and it is removed by the demethylase ALKBH1. Decrease of genomic DNA 6mA promotes tumorigenesis and is associated with poor prognosis for cancer patients. © 2018 Elsevier Inc.

语种： 英文