摘要:
The assembly of the HIV-1 immature capsid (HIC) is an essential step in the virus life cycle. In vivo, the HIC is composed of [Formula: see text] hexameric building blocks, and it takes 5-6 min to complete the assembly process. The involvement of numerous building blocks and the rapid timecourse makes it difficult to understand the HIC assembly process. In this work, we study HIC assembly in vivo by using differential equations. We first obtain a full model with 420 differential equations. Then, we reduce six addition reactions for separate building blocks to a single complex reaction. This strategy reduces the full model to 70 equations. Subsequently, the theoretical analysis of the reduced model shows that it might not be an effective way to decrease the HIC concentration at the equilibrium state by decreasing the microscopic on-rate constants. Based on experimental data, we estimate that the nucleating structure is much smaller than the HIC. We also estimate that the microscopic on-rate constant for nucleation reactions is far less than that for elongation reactions. The parametric collinearity investigation testifies the reliability of these two characteristics, which might explain why free building blocks do not readily polymerize into higher-order polymers until their concentration reaches a threshold value. These results can provide further insight into the assembly mechanisms of the HIC in vivo.
摘要:
Fractional-order gene regulatory networks with time delay (DFGRNs) have proven that they are more suitable to model gene regulation mechanism than integer-order. In this paper, a novel DFGRN is proposed. The existence and uniqueness of the equilibrium point for the DFGRN are proved under certain conditions. On this basis, the conditions on the global asymptotic stability are established by using the Lyapunov method and comparison theorem for the DFGRN, and the stability conditions are dependent on the fractional-order q. Finally, numerical simulations show that the obtained results are reasonable.
摘要:
Abstract: Many merchants are deeply troubled by the problem of filling orders caused by insufficient stock of goods, and the problem of filling orders mainly has two problems: the occupation of cash flow and the problem of inventory. Therefore, effective and reasonable replenishment strategy is an urgent problem for merchants. Based on the sales data of business over the years, and on the basis of data preprocessing, this paper studies the sales volume of a business from several aspects, such as model hypothesis, model establishment and solution. According to the establishment of ARIMA model, and according to ARIMA model, the sales volume in the next few days is fitted and predicted, and then the results are tested by Markov model, which provides a theoretical basis for the replenishment and inventory of the merchant.#@#@#摘要: 许多商家对于因货物存量不足而导致的补单问题存在极大的困扰,且补单问题主要存在两个问题:对现金流的占用和库存问题。因此,有效解决合理的补单策略是商家们急需解决的问题。本文基于某商家的历年销量数据,在数据预处理的基础上,从模型假设、模型建立与求解等几个方面对该商家的销售量数据进行ARIMA模型的建立,并根据ARIMA模型对未来几天的销售量进行拟合和预测分析,然后用马尔可夫模型进行结果检验,为该商家的补单及存货提供理论依据。
作者机构:
College of Information Science and Technology,Hunan Agricultural University
会议名称:
2019计算智能、工程与信息技术世界大会
会议时间:
2019-06-29
会议地点:
中国上海
会议论文集名称:
Proceedings of The 2019 World Congress on Computational Intelligence, Engineering and Information Technology (WCEIT 2019)
摘要:
In order to obtain the fluctuation and cycles of intra-annual and inter-annual,the weekly data was studied and analyzed of the pig price in China.However,the study shows the fluctuation is high at both ends and low in the middle of the year and the cycle of price variation is about 3 years.Based on this research,a comprehensive analysis for the factors affecting the price fluctuation is supply,demand and external.Further,the stepwise regression analysis and the correlation coefficient analysis are used to analyze the influencing factors of pig price.Whatever,the analysis shows that pork price,piglet price,corn price and soybean price have significant fluctuations for pig price.