摘要：
Emotional mimicry plays a vital role in understanding others’ emotions and has been found to be modulated by social contexts, especially group membership. However, the neural mechanisms underlying this modulation remain unclear. We explored whether and how group membership modulated emotional mimicry using a multimodal method combining facial electromyography (fEMG) and electroencephalography (EEG). We instructed participants to passively view dynamic emotional faces (happy vs. angry) of others (in-group vs. out-group) and simultaneously recorded their fEMG and EEG responses. Then, we conducted combined analyses of fEMG-EEG by splitting the EEG trials into two mimicry intensity categories (high-intensity mimicry vs. low-intensity mimicry) according to fEMG activity. The fEMG results confirmed the occurrence of emotional mimicry in the present study but failed to find a group membership effect. However, the EEG results showed that participants mimicked in-group happiness and anger more than out-group. Importantly, this in-group preference involved different neural mechanisms in happiness and anger mimicry. In-group preference for happiness mimicry occurred at multiple neural mechanisms such as N1 (at P7, Pz, and P8), P2 (at Pz and P8), N2 (at P8), and P3 (at P7, Pz, and P8); in-group preference for anger mimicry occurred at P1 (at P7) and P2 (at Pz). Our findings provide new neural evidence for the effect of group membership on emotional mimicry by uncovering the temporal dynamics of this effect.
摘要：
Sleep loss robustly disrupts mood and emotion regulation in healthy individuals but can have a transient antidepressant effect in a subset of patients with depression. The neural mechanisms underlying this paradoxical effect remain unclear. Previous studies suggest that the amygdala and dorsal nexus (DN) play key roles in depressive mood regulation. Here, we used functional MRI to examine associations between amygdala- and DN-related resting-state connectivity alterations and mood changes after one night of total sleep deprivation (TSD) in both healthy adults and patients with major depressive disorder using strictly controlled in-laboratory studies. Behavioral data showed that TSD increased negative mood in healthy participants but reduced depressive symptoms in 43% of patients. Imaging data showed that TSD enhanced both amygdala- and DN-related connectivity in healthy participants. Moreover, enhanced amygdala connectivity to the anterior cingulate cortex (ACC) after TSD associated with better mood in healthy participants and antidepressant effects in depressed patients. These findings support the key role of the amygdala-cingulate circuit in mood regulation in both healthy and depressed populations and suggest that rapid antidepressant treatment may target the enhancement of amygdala-ACC connectivity.
摘要：
Resting-state functional magnetic resonance imaging (fMRI) with graph theoretical modeling has been increasingly applied for assessing whole brain network topological organization, yet its reproducibility remains controversial. In this study, we acquired three repeated resting-state fMRI scans from 16 healthy controls during a strictly controlled in-laboratory study and examined the test-retest reliability of seven global and three nodal brain network metrics using different data processing and modeling strategies. Among the global network metrics, the characteristic path length exhibited the highest reliability, whereas the network small-worldness performed the poorest. Nodal efficiency was the most reliable nodal metric, whereas betweenness centrality showed the lowest reliability. Weighted global network metrics provided better reliability than binary metrics, and reliability from the AAL90 atlas outweighed those from the Power264 parcellation. Although global signal regression had no consistent effects on the reliability of global network metrics, it slightly impaired the reliability of nodal metrics. These findings provide important implications for the future utility of graph theoretical modeling in brain network analyses.
摘要：
BACKGROUND: Major depressive disorder (MDD) is a highly prevalent mood disorder affecting more than 300 million people worldwide. Biased processing of negative information and neural hyper-responses to negative events are hallmarks of depression. This study combined cross-sectional and longitudinal experiments to explore both persistent and resolved neural hyper-responses to negative outcomes from risky decision making in patients with current MDD (cMDD) and remitted MDD (rMDD). METHODS: A total of 264 subjects participated in the cross-sectional study, including 117 patients with medication-naïve, first-episode current depression; 45 patients with rMDD with only 1 episode of depression; and 102 healthy control subjects. Participants completed a modified balloon analog risk task during functional magnetic resonance imaging. In the longitudinal arm of the study, 42 patients with cMDD were followed and 26 patients with rMDD were studied again after 8 weeks of antidepressant treatment. RESULTS: Patients with cMDD showed hyper-responses to loss outcomes in multiple limbic regions including the amygdala and ventral anterior cingulate cortex (vACC). Amygdala but not vACC hyperactivity correlated with depression scores in patients with cMDD. Furthermore, amygdala hyperactivity resolved while vACC hyperactivity persisted in patients with rMDD in both cross-sectional and longitudinal studies. CONCLUSIONS: These findings provide consistent evidence supporting differential patterns of amygdala and vACC hyper-responses to negative outcomes during depression remission. Amygdala hyperactivity may be a symptomatic and state-dependent marker of depressive neural responses, while vACC hyperactivity may reflect a persistent and state-independent effect of depression on brain function. These findings offer new insights into the neural underpinnings of depression remission and prevention of depression recurrence.
期刊：
Journal of Affective Disorders,2023年321:66-73 ISSN：0165-0327
通讯作者：
Changlian Tan
作者机构：
[Fan, Jie; Zhu, Xiongzhao; Liu, Wanting; Gan, Jun; Yi, Jinyao] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China.;[Gan, Jun] Hunan Agr Univ, Coll Educ, Changsha 410128, Hunan, Peoples R China.;[Fan, Jie; Zhu, Xiongzhao; Liu, Wanting; Yi, Jinyao] Cent South Univ, Medial Psychol Inst, Changsha 410011, Hunan, Peoples R China.;[Fan, Jie; Zhu, Xiongzhao] Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.;[Tan, Changlian] Cent South Univ, Dept Radiol, Xiangya Hosp 2, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.
通讯机构：
[Changlian Tan] D;Department of Radiology, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China
摘要：
BACKGROUND: Despite the several researches on the correlates of insight in psychosis, less is known regarding the specificity of disease diagnosis on the relationship between insight and the correlates. The current study sought to explore the effects of insight and disease diagnosis on those in patients with obsessive-compulsive disorder (OCD) and patients with schizo-obsessive disorder (SOD). METHODS: We evaluated clinical symptoms and neurocognitions among 111 patients (including 41 OCD with good insight, 40 OCD with poor insight, 14 SOD with good insight and 16 SOD with poor insight. Gray matter volume and spontaneous neural activity were also examined by analyzing the voxel-based morphometry and amplitude of low frequency fluctuation (ALFF), respectively. RESULTS: Interactive effects of insight and diagnosis was found on working memory and the gray matter volume in right superior and middle temporal gyrus. Main effect of insight was found on working and visual memory, compulsion and obsession, and ALFF in right middle and superior occipital cortex. Main effect of diagnosis was found on severity of compulsion, relative verbal IQ, executive function, verbal and visual memory, working memory and ALFF in precuneus, medial superior frontal gyrus, anterior cingulate and paracingulate gyri, and inferior parietal, postcentral gyrus, paracentral lobule. CONCLUSIONS: As a common feature in mental disorders, insight has its own special influence on neurocognition and possible structural/functional alterations in brain, and the influence is partly dependent of disease diagnosis.
期刊：
Journal of Affective Disorders,2022年301:463-471 ISSN：0165-0327
通讯作者：
Yu-Tao Xiang
作者机构：
[Liu, Rui; Qi, Han; Zhang, Ling; Chen, Xu; Feng, Yuan] Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.;[Liu, Rui; Qi, Han; Zhang, Ling; Chen, Xu; Feng, Yuan] Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing Anding Hosp, Beijing, Peoples R China.;[Liu, Rui; Qi, Han; Zhang, Ling; Chen, Xu; Feng, Yuan] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China.;[Liu, Rui; Xiang, Yu-Tao] Univ Macau, Fac Hlth Sci, Inst Translat Med, Unit Psychiat,Dept Publ Hlth & Med Adm, Macau, Peoples R China.;[Liu, Rui; Xiang, Yu-Tao] Univ Macau, Ctr Cognit & Brain Sci, Macau, Peoples R China.
通讯机构：
[Yu-Tao Xiang] U;Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China<&wdkj&>Center for Cognitive and Brain Sciences, University of Macau, Macao SAR, China<&wdkj&>Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China
摘要：
BACKGROUND: This study examined the extent to which the network structure of anxiety and depression among adolescents identified during the peak of the COVID-19 pandemic could be cross-validated in a sample of adolescents assessed after the COVID-19 peak. METHODS: Two cross-sectional surveys were conducted between February 20 and 27, 2020 and between April 11 and 19, 2020, respectively. Depressive and anxiety symptoms were assessed using the 20-item Center for Epidemiological Studies-Depression and 7-item Generalized Anxiety Disorder, respectively. Anxiety-depression networks of the first and second assessments were estimated separately using a sparse Graphical Gaussian Model combined with the graphical least absolute shrinkage and selection operator method. A Network Comparison Test was conducted to assess differences between the two networks. RESULTS: The most central symptoms in the first and second survey networks were Depressed affect and Nervousness. Compared with connections in the first survey network, connections in the second survey network analysis between Relax-Nervousness-Depressed affect-Interpersonal problems (diff, contrast: second survey-first survey. diff=-0.04, P=0.04; diff=-0.03, P=0.03; diff=-0.03, P=0.04), and Irritability-Somatic complaints (diff=-0.04, P=0.02) were weaker while connections of Somatic complaints-Nervousness (diff=0.05, P<0.001), Somatic complaints-Depressed affect (diff=0.03, P=0.009), and Irritability-Control worry-Restlessness (diff=0.02, P=0.03; diff=0.05, P=0.02) were stronger. CONCLUSIONS: Depressed affect emerged as a robust central symptom and bridge symptom across Anxiety-Depression networks. Considering the negative impact of depression and anxiety on daily life, timely interventions targeting depressed affect should be implemented to reduce the co-occurrence of anxious and depressive symptoms among adolescents during the COVID-19 pandemic.
关键词：
Cultural difference;Ensemble coding;In-group vs. out-group faces;Subjective similarity
摘要：
It is well established that ensemble coding is regulated by physical similarity and variance in a set of stimuli. For example, observers are more accurate at judging the mean size of objects in a set if the overall size variance in the set is small. However, sometimes similarity among set members can be purely subjective. For example, faces from another race tend to look more similar than faces from one’s own race. Very little is known about whether such subjective similarity also regulates ensemble coding in the same manner as objective similarity. To investigate this question, we had British and Chinese participants view sets of four faces that were of either own-race or other-race, own-gender or other-gender. After viewing each set the task was to judge whether a test face was presented in the set. Our results showed that, as demonstrated in prior research, participants often mistook a morphed set average to be a member of the set. Critically, this tendency to average a face set was not stronger for other-race faces. Hence contrary to objective similarity, subjectively perceived similarity in the other-race faces does not facilitate ensemble coding. The results in our British group also replicated de Fockert and Gautrey’s (Psychonomic Bulletin & Review 20 (3), 468-473, 2013) own-gender effect, where observers showed more averaging for own-gender faces. However, our Chinese subjects displayed the same level of averaging for both genders. This suggests a cultural difference in ensemble coding, where the own-gender bias may be overridden by a stronger tendency to employ ensemble coding in Chinese participants.
摘要：
Our prior research demonstrated that the right temporoparietal junction (rTPJ) exerted a modulatory role in ingroup bias in emotional mimicry. In this study, two experiments were conducted to further explore whether the rTPJ is a neural region for emotional mimicry or for the modulation of emotional mimicry by group membership in a sham-controlled, double-blinded, between-subject design. Both experiments employed non-invasive transcranial direct current stimulation (tDCS) to temporarily change the cortical excitability over the rTPJ and facial electromyography (fEMG) to measure facial muscle activations as an index of emotional mimicry. After the anodal or sham stimulation, participants in Experiment 1 passively viewed a series of happy clips, while participants in Experiment 2 viewed happy clips performed by ethnic ingroup and outgroup models. fEMG analyses revealed that participants in Experiment 1 showed the same degree of happy mimicry for both tDCS conditions (anodal vs. sham) and participants in Experiment 2 showed an ingroup bias in happy mimicry in the sham condition, which disappeared in the anodal condition. Taken together, the present study demonstrated that rTPJ plays a role in the modulation of emotional mimicry by group membership.
摘要：
BACKGROUND: Few studies exist on sibling bullying or even sibling aggression more generally in the past 30 years. Studies of sibling bullying have shown that sibling bullying may associate with depression, anxiety, self-harm, suicide ideation in early adulthood. Nevertheless, few studies have explored the relationship between sibling victimization types and the occurrence of psychosis, not to mention that psychotic-like experiences (PLEs) always occur before psychotic disorders. Therefore, the current study aims to examine the association between sibling bullying and PLEs among children age 11-16 years in China. METHOD: This is a cross-sectional study which included 3231 students from eight junior middle schools in three cities of Hunan Province, China. Frequency and types of sibling bullying was assessed with Sibling Bullying Questionnaire and PLEs was assessed with Community Assessment Psychic Experiences-42. RESULTS: The percentage of sibling bullying were 12.9% for victimization and 10.8% for perpetration. Sibling bullying plays as an independent influence factor for all subtypes of PLEs, and verbal victimization was the most important risk factor in developing different subtypes of PLEs followed by physical victimization and verbal perpetration. CONCLUSION: The current study found that sibling bullying is associated with PLEs. Intervention programs should be conducted to focus on those children and adolescents who are involved in multiple types of sibling victimization or perpetration.
通讯机构：
[Li, Xiaoma] H;Hunan Agr Univ, Coll Landscape Architecture & Art Design, Inst Educ, Hunan Prov Key Lab Landscape Ecol & Planning & De, Changsha 410128, Peoples R China.
关键词：
spatiotemporal change;pseudo-invariant feature;relative normalization;urban expansion;urban heat island
摘要：
The Landsat land surface temperature (LST) product is widely used to understand the impact of urbanization on surface temperature changes. However, directly comparing multi-temporal Landsat LST is challenging, as the observed LST might be strongly affected by climatic factors. This study validated the utility of the pseudo-invariant feature-based linear regression model (PIF-LRM) in normalizing multi-temporal Landsat LST to highlight the urbanization impact on temperature changes, based on five Landsat LST images during 2000–2018 in Changsha, China. Results showed that LST of PIFs between the reference and the target images was highly correlated, indicating high applicability of the PIF-LRM to relatively normalize LST. The PIF-LRM effectively removed the temporal variation of LST caused by climate factors and highlighted the impacts of urbanization caused land use and land cover changes. The PIF-LRM normalized LST showed stronger correlations with the time series of normalized difference of vegetation index (NDVI) than the observed LST and the LST normalized by the commonly used mean method (subtracting LST by the average, respectively for each image). The PIF-LRM uncovered the spatially heterogeneous responses of LST to urban expansion. For example, LST decreased in the urban center (the already developed regions) and increased in the urbanizing regions. PIF-LRM is highly recommended to normalize multi-temporal Landsat LST to understand the impact of urbanization on surface temperature changes from a temporal point of view.
摘要：
Humans tend to show congruent facial expressions automatically in reaction to their partners which is defined as emotional mimicry. Although occurring unconsciously, this tendency has been proven to be modulated by social contextual factors such as group membership. Ingroup bias in emotional mimicryhas been well-documentedin previous research; however, few studies have investigated the underlying mechanism. Based on the mimicry-as-social-regulatormodel, this study explored whether the ingroup bias in emotional mimicry arises from the greater self-ingroup overlap. By recording participants' facial electromyographic responses while passively viewing dynamic emotional clips performed by either racial ingroup or outgroup actors, Study 1 validated the presence of ingroup bias in the mimicry of happiness, but not anger. Using asimilar procedure in Study 2, anew sample was employed (N=37), and ameasurement of self-other overlaps via the Inclusion of the Other in the Self Scale was added. The results of Study 2 reproduced the ingroup bias in happy mimicry, and further demonstrated that the effect of group membership on emotional mimicry was mediated by the self-other overlap. In summary, this study provides evidence that the level of interpersonal closeness predicts emotional mimicry.
摘要：
BACKGROUND: Recent work suggests that the social component of anhedonia is more associated with suicide ideation than the other component of pleasure. The present study investigated the differential effects of state and trait social anhedonia on suicidal ideation across two undergraduate samples based on the Interpersonal Theory and Three-Step Theory of Suicide. METHODS: State social anhedonia was assessed with a single item (Loss of Interest in People) extracted from the Beck Depression Inventory, while trait social anhedonia was assessed using the Anticipatory and Consummatory Interpersonal Pleasure Scale. Suicidal ideation was re-administered at a 3-month follow-up. RESULTS: In Study 1, higher state social anhedonia was associated with greater levels of suicidal ideation, while trait social anhedonia moderated the relationship between thwarted belongingness, perceived burdensomeness and suicidal ideation. In Study 2, state social anhedonia was margin significant predictor of suicidal ideation, while trait social anhedonia moderated the relationship between psychological pain and suicidal ideation. CONCLUSIONS: These findings confirmed the presence of two different effects on suicidal ideation in state and trait social anhedonia: state social anhedonia directly was associated with suicidal ideation, while trait social anhedonia was indirectly related through their effects on other risk factors of suicidality.
摘要：
Adolescents with childhood trauma may be associated with psychotic-like experiences (PLEs) and is at high risk for later development of psychoses. Exploring early age risk factors for childhood trauma may provide useful information for prevention of mental disorders and improvement of mental health, yet no studies have examined the association between exposure to specific forms of trauma and different types of PLEs in a sample of Chinese adolescents. Thus, the Childhood Trauma Questionnaire-Short Form was used to measure five types of childhood trauma (emotional abuse, EA; physical abuse, PA; sexual abuse, SA; emotional neglect, EA; physical neglect, PA) in junior middle school students. And the positive subscale of Community Assessment of Psychic Experiences divided into four types (bizarre experiences, perceptual abnormalities, persecutory ideation and magical thinking) was used to measure PLEs. Then the possible associations among demographic information and specific types of childhood trauma on specific forms of PLEs was compared. The rates of EA, PA, SA, EA and PA were 14.2%, 13.0%, 16.1%, 60.0%, and 78.6%, respectively. Moreover, childhood trauma seems to be a main role in the development of PLE, and EA and SA patients are particularly likely to experience PLEs.
摘要：
BACKGROUND: Recent works suggest recent changes in anhedonia may be specifically predictive of key elements of psychopathology. The present study aimed to identify the trajectories of state anhedonia and recent changes in anhedonia, and to investigate their associations with other psychiatric syndromes over time. METHODS: A total of 859 college students were assessed at three time points. State anhedonia was assessed using the Snaith Hamilton Pleasure Scale and recent changes in anhedonia were assessed with a subscale extracted from the Symptom Check-List-90. The Latent Growth Curve Modelling analysis was used to analyze trajectories. Associations with anhedonia were investigated with logistic regression models. RESULTS: Three state anhedonia trajectories and two recent changes in anhedonia trajectories were identified. The decreasing trajectory was the most prevalent class in both two types of anhedonia. Depression and suicidal ideation predicted recent changes in anhedonia whereas other psychiatric syndromes predicted state anhedonia. CONCLUSIONS: The current study highlighted the development trajectories of different measures of anhedonia. The results showed that the relationships between anhedonia and psychiatric syndromes were different according to the kind of anhedonia.
摘要：
Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patients will exhibit altered spontaneous brain activity as compared to healthy controls (HC). Methods: Resting-state fMRI data were acquired in 37 OCPD patients and 37 matched HC. Amplitudes of low-frequency fluctuation (ALIT) were calculated and compared between the two groups. Correlation analysis was performed between regional ALFF values and OCPD severity scores. Results: Significant group differences in regional ALFF were found in multiple brain regions. Compared to HCs, OCPD subjects had increased ALFF in bilateral caudate, left precuneus, left insula, and left medial superior frontal gyrus, and decreased ALFF in the right fusiform gyrus and left lingual gyrus. The ALFF values in the left precuneus correlated with OCPD severity scores. Limitations: We excluded patients with comorbidity and did not conduct cognitive function assessments. Our findings are also limited to cross-sectional analysis. Conclusions: OCPD patients exhibit altered spontaneous neural activity as compared to healthy controls in multiple brain regions, which may reflect different characteristic symptoms of OCPD pathophysiology, including cognitive inflexibility, excessive self-control, lower empathy, and visual attention bias. (C) 2019 University of Cape Town. Published by Elsevier B.V.
