Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
作者：
He, Shaoping;Yu, Qifang;He, Yujia;Hu, Ruizhi;Xia, Siting;...
期刊：
Poultry Science ,2019年98(12):6378-6387 ISSN：0032-5791
通讯作者：
He, Jianhua
作者机构：
[He, Yujia; Yu, Qifang; He, Shaoping; Xia, Siting; He, Jianhua; Hu, Ruizhi] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[He, Jianhua] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
关键词：
broilers;heat stress;innate immune;inflammation;resveratrol
摘要：
The aim of this study was to investigate the effect of dietary resveratrol supplementation on innate immunity and inflammatory responses in the spleen of yellow-feather broilers under heat stress. A total of 288 yellow-feather broilers of 28-day-old were randomly assigned to 3 treatment groups with 6 replicates. A thermo-neutral group (TN) (24 +/- 2 degrees C) received a basal diet and another 2 heat-stressed groups (37 +/- 2 degrees C for 8 h/D and 24 +/- 2 degrees C for the remaining time) were fed the basal diet (HT) or basal diet with 500 mg/kg resveratrol (HT+Res) for 14 consecutive days. The results showed that heat stress decreased (P < 0.05) the growth index of thymus, spleen, and bursa of Fabricius, reduced (P < 0.05) the levels of complement C3 and C4 in serum. Heat stress also caused activation of inflammatory immune responses evidenced by increased (P < 0.05) the mRNA abundance of HSP (heat shock protein) 70, toll-like receptor (TLR)1, TLR4, TLR5, myeloid differentiation factor-88 (MyD88), nucleotide-binding oligomerization domain 1 (NOD1), Dectin-1, transforming growth factor-beta-activated kinase 1 (TAK1), interleukin (IL)-1, IL-4, IL-6, and tumor necrosis factor (TNF)-alpha, but decreased the mRNA abundance of interferon (IFN)-gamma, activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPK), and phosphoinositide-3 kinases-protein kinase B (PI3K/AKT) signaling pathways. Dietary supplementation with resveratrol improved (P < 0.05) the growth index of thymus, spleen and bursa Fabricius, and increased (P < 0.05) the serum level of complement C3 under heat stress. In addition, resveratrol reduced (P < 0.05) the mRNA abundance of HSP70, TLR4, TLR5, NOD1, Dectin-1, and TAK1, and inhibited the NF-kappaB, MAPK and PI3K/AKT signaling pathway via down-regulated the phosphorylation of p65, extracellular signal-regulated kinases 1/2, c-Jun N-terminal protein kinase and AKT, as well as decreased the inflammatory cytokines expression, including IL-1, IL-4, IL-6, and TNF-alpha in the spleen under heat stress. Collectively, dietary resveratrol could have beneficial effects to regulate innate immunity and inflammatory response, via inhibiting the activation of NF-kappaB, MAPK, and PI3K/AKT signaling pathways induced by heat stress in the spleen.
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英文
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壳聚糖的生物学功能及其在畜禽生产中的应用
作者：
杨玲;何荣香;马玉静;贺建华
期刊：
动物营养学报 ,2019年31(3):1037-1043 ISSN：1006-267X
作者机构：
湖南农业大学动物科学技术学院;[何荣香; 马玉静; 杨玲; 贺建华] 湖南畜禽安全生产协同创新中心
关键词：
壳聚糖;生长性能;脂肪代谢;免疫力;抗氧化
摘要：
壳聚糖( chitosan)是甲壳素脱乙酰基后的产物,是天然多糖中唯一的碱性多糖,其自然资源丰富、安全无毒、不产生耐药性、生产成本低,具有改善动物生长性能、增强机体免疫力、调节脂肪代谢、抗菌抑菌和抗氧化等多种生物学功能,被认为是具有广泛开发前景的绿色添加剂.本文就壳聚糖生物学特性、生理功能及其在畜禽生产中的应用现状进行综述,以期为其在畜禽生产中的应用提供参考依据.
语种：
中文
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Intervention with α-ketoglutarate ameliorates colitis-related colorectal carcinoma via modulation of the gut microbiome
作者：
Li, Si;Fu, Chenxing;Zhao, Yurong;He, Jianhua*
期刊：
BioMed Research International ,2019年2019:1-9 ISSN：2314-6133
通讯作者：
He, Jianhua
作者机构：
[Fu, Chenxing; Li, Si; He, Jianhua; Zhao, Yurong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.
通讯机构：
[He, Jianhua] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.
摘要：
The intestinal microbiome plays a crucial role in promoting intestinal health, and perturbations to its constitution may result in chronic intestinal inflammation and lead to colorectal cancer (CRC). α-Ketoglutarate is an important intermediary in the NF-B-mediated inflammatory pathway that maintains intestinal homeostasis and prevents initiation of intestinal inflammation, a known precursor to carcinoma development. The objective of this study was to assess the potential protective effects of α-ketoglutarate intervention against CRC development, which may arise due to its known anti-inflammatory and antitumour effects. CRC was induced in C57BL/6 mice using azoxymethane (AOM) and dextran sulfate sodium (DSS). Tumour frequency, histological rating, and colonic microbiota were assessed in colonic samples. The findings demonstrated that α-ketoglutarate offered significant protection against CRC development in mice. Furthermore, α-ketoglutarate also exhibited immunomodulatory effects mediated via downregulation of interleukin (IL)-6, IL-22, tumour necrosis factor (TNF)-α, and IL-1β cytokines. Finally, intervention with α-ketoglutarate tended to minimise the frequency of opportunistic pathogens (Escherichia and Enterococcus) while increasing the populations of Akkermansia, Butyricicoccus, Clostridium, and Ruminococcus. Taken together, our findings show that dietary α-ketoglutarate intervention may protect against inflammation-related CRC. © 2019 Si Li et al.
语种：
英文
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植物多糖对断奶仔猪小肠黏膜形态及肠黏膜屏障功能的影响
作者：
谢红兵;邹云;刘丽莉;杨永生;贺建华
期刊：
中国兽医学报 ,2019年39(1):150-157,187 ISSN：1005-4545
作者机构：
湖南农业大学动物科学技术学院,湖南长沙41012;[杨永生; 刘丽莉; 谢红兵; 邹云; 贺建华] 湖南农业大学
关键词：
植物多糖;黏膜形态;黏膜屏障;仔猪
摘要：
旨在探讨断奶仔猪饲粮中单独或联合添加黄芪多糖、牛膝多糖及白术多糖对其小肠黏膜形态及肠黏膜屏障功能的影响。选取256头35日龄的杜长大三元杂交断奶仔猪,随机分为8个组,每组4个重复,每个重复8头猪,采用三因素两水平(2×2×2)试验设计,饲粮中黄芪多糖、白术多糖和牛膝多糖的添加水平均为0,800mg/kg,试验共进行28d。结果显示:植物多糖能显著提高断奶仔猪十二指肠、空肠和回肠的黏膜绒毛高度,提高绒腺比(P<0.05),3种多糖联用效果最适。与对照组相比,多糖组断奶仔猪回肠V/C比值显著提高(P<0.05),各单一多糖组之间差异不显著(P>0.05),3种多糖联合添加与两两添加及单一添加相比显著提高了V/C比值(P<0.05)。多糖组断奶仔猪血清中二胺氧化酶(DAO)的活性、血清中内毒素(ET)含量及D-乳糖的含量均显著降低(P<0.05),3种多糖联用效果最适。多糖能显著提高断奶仔猪肠道黏膜Occludin、Claudin和ZO-1的基因表达量(P<0.05)。单一添加黄芪多糖、白术多糖及牛膝多糖能显著提高断奶仔猪肠道钠-葡萄糖共转运载体1(SGLT1)的mRNA相对表达量(P<0.05),对葡萄糖转运载体2(GLUT2)mRNA相对表达量有提高的趋势,但差异不显著(P>0.05)。多糖两两联用及3种多糖联合添加能显著提高断奶仔猪肠道SGLT1和GLUT2mRNA相对表达量(P<0.05)。结果表明,在断奶仔猪饲粮中添加植物多糖可显著改善断奶仔猪肠道黏膜形态结构和肠道的通透性,其机制可能与植物多糖改善断奶仔猪肠黏膜屏障功能作用有关。
语种：
中文
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植物多糖的功能性研究进展及其在动物生产中的应用
作者：
杨玲;胡睿智;夏嗣廷;贺建华
期刊：
动物营养学报 ,2019年31(6):2534-2543 ISSN：1006-267X
作者机构：
湖南农业大学动物科学技术学院, 长沙, 410128;湖南畜禽安全生产协同创新中心, 湖南畜禽安全生产协同创新中心, 长沙, 410128;[杨玲; 胡睿智; 夏嗣廷] 湖南农业大学动物科学技术学院, 长沙, 410128 湖南畜禽安全生产协同创新中心, 湖南畜禽安全生产协同创新中心, 长沙, 410128;[贺建华] 湖南农业大学动物科学技术学院, 长沙, 410128
关键词：
植物多糖;抗氧化;免疫;抗肿瘤;动物生产
摘要：
植物多糖作为多功能的天然植物成分,具有来源广泛、高效、无毒副作用等特点。植物多糖作为绿色饲料添加剂,不仅可以增强机体免疫力、抗病力、抗应激能力,还可以调节肠道微生物平衡,改善畜产品品质。本文主要就植物多糖的结构、生理功能及其在动物生产中的应用进行综述,以期为其在动物生产中的应用提供参考依据。
语种：
中文
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血根碱和牛膝多糖对黄羽肉鸡生长性能及免疫性能的影响
作者：
欧淑琦;刘祝英;郭丹;贺建华
期刊：
动物营养学报 ,2019年31(1):360-368 ISSN：1006-267X
作者机构：
湖南农业大学动物科学技术学院,长沙,410128;北京中农弘科生物技术有限公司,北京,102209
关键词：
血根碱;牛膝多糖;生长性能;免疫性能
摘要：
本试验旨在研究血根碱和牛膝多糖单独或联合添加对黄羽肉鸡生长性能及免疫性能的影响.试验选用1日龄的黄羽肉鸡300只, 随机分成5组, 每组6个重复, 每个重复10只.对照组饲喂基础饲粮, 血根碱组在基础饲粮中添加0.75 mg/kg血根碱, 牛膝多糖组在基础饲粮中添加400 mg/kg牛膝多糖, 血根碱+牛膝多糖组在基础饲粮中添加0.75 mg/kg血根碱和400 mg/kg牛膝多糖, 抗生素组在基础饲粮中添加300 mg/kg杆菌肽锌.试验期56 d, 分为2个阶段 (1～28日龄、29～56日龄) 进行.结果表明:1) 试验处理对黄羽肉鸡的1～28日龄、29～56日龄平均日采食量、平均日增重以及1～28日龄料重比均有显著影响 (P<0.05) .29～56日龄阶段, 血根碱组、牛膝多糖组和血根碱+牛膝多糖组的平均日采食量和平均日增重均显著高于对照组和抗生素组 (P<0.05) .血根碱和牛膝多糖对1～28日龄、29～56日龄的平均日采食量均有显著的互作效应 (P<0.05) .2) 28日龄时, 血根碱组、牛膝多糖组和血根碱+牛膝多糖组外周血淋巴细胞增殖率均显著高于对照组和抗生素组 (P<0.05) ; 56日龄时, 血根碱+牛膝多糖组外周血淋巴细胞增殖率最高, 与牛膝多糖组差异不显著 (P>0.05) , 但显著高于对照组、血根碱组和抗生素组 (P<0.05) .血根碱和牛膝多糖对28日龄外周血淋巴细胞增殖率存在显著的互作效应 (P<0.05) .3) 28日龄时, 与对照组相比, 添加血根碱和/或牛膝多糖均在一定程度上提高了黄羽肉鸡的免疫器官指数 (P>0.05) , 但血根碱和牛膝多糖对黄羽肉鸡免疫器官指数没有显著的互作效应 (P>0.05) .由此得出, 血根碱和牛膝多糖对黄羽肉鸡有促生长和提高机体免疫力的作用, 且两者对生长性能和外周血淋巴细胞增殖率都有一定的互作效应.
语种：
中文
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白藜芦醇的生物学功能及其在动物生产中的应用
作者：
马玉静;何荣香;杨玲;贺建华
期刊：
中国畜牧兽医 ,2019年46(11):3234-3243 ISSN：1671-7236
作者机构：
湖南农业大学动物科学技术学院,长沙,410128
关键词：
白藜芦醇;抗氧化;抗炎;肠道
摘要：
白藜芦醇是一种含有茋类结构的天然非黄酮类多酚类化合物,具有多种生物学功能:可抑制和清除体内过量的自由基,激活机体抗氧化酶系统,发挥抗氧化功能;通过调控一系列炎症或抗炎通路,降低机体内炎性因子表达,降低炎症反应。白藜芦醇还具有调节糖脂代谢、保护心血管、抗癌、抗病毒等重要生物学功能,且具有安全高效、无残留、不产生耐药性的优点,在动物生产中的应用具有广阔的应用前景。动物试验表明,白藜芦醇能提高肉鸡平均日增重、平均采食量,降低料重比;提高育肥猪肉品质,增加背最长肌pH 24 h、红度、粗蛋白质和肌红蛋白含量,还可降低24 h后肌肉亮度、剪切力、滴水损失、背膘厚度;提高动物机体内抗氧化酶活性;降低炎性因子的产生,增强机体免疫;改善肠道菌群组成和肠道黏膜形态;抑制癌细胞的生成。本试验针对白藜芦醇生物学特性、生理功能及其在畜禽生产中的应用现状进行综述,旨在为其在畜禽生产中的应用提供参考依据。
语种：
中文
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短链脂肪酸的生理功能及其在畜禽生产中的应用
作者：
陈福;何邵平;田科雄;贺建华
期刊：
动物营养学报 ,2019年31(7):3039-3048 ISSN：1006-267X
作者机构：
湖南农业大学动物科学技术学院,长沙410128;[何邵平; 陈福; 田科雄; 贺建华] 湖南农业大学
关键词：
短链脂肪酸;生理功能;畜禽生产;肠道菌群
摘要：
短链脂肪酸(SCFAs)是指碳原子数目不大于6的脂肪酸,在肠道中以乙酸、丙酸和丁酸含量居高。在生物体内SCFAs 具有提供能量、调节免疫、调控肠道细胞代谢、维持水电解质平衡、改善肠道菌群结构等多种重要的生物学功能。本文就机体内SCFAs 的产生、SCFAs 的生理功能及其在畜禽生产中的应用研究进展进行综述,旨在为SCFAs 的开发利用提供理论依据。
语种：
中文
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Polyphenols as Potential Attenuators of Heat Stress in Poultry Production
作者：
Hu, Ruizhi;He, Yujia;Arowolo, Muhammed Adebayo;Wu, Shusong* ;He, Jianhua*
期刊：
Antioxidants ,2019年8(3):67- ISSN：2076-3921
通讯作者：
Wu, Shusong;He, Jianhua
作者机构：
[Arowolo, Muhammed Adebayo; Wu, Shusong; Wu, SS; He, Jianhua; Hu, Ruizhi] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.;[He, Yujia] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Wu, SS; He, J] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
关键词：
heat stress;oxidative stress;polyphenols;poultry
摘要：
Heat stress is a non-specific physiological response of the body when exposed to high ambient temperatures, which can break the balance of body redox and result in oxidative stress that affects growth performance as well as the health of poultry species. Polyphenols have attracted much attention in recent years due to their antioxidant ability and thus, can be an effective attenuator of heat stress. In this paper, the potential mechanisms underlying the inhibitory effect of polyphenols on heat stress in poultry has been reviewed to provide a reference and ideas for future studies related to polyphenols and poultry production.
语种：
英文
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短链脂肪酸的生理功能及其在仔猪生产中的应用
作者：
蔡懿鑫;蒋慧姣;孔祥峰;贺建华
期刊：
中国畜牧杂志 ,2019年55(11):30-34 ISSN：0258-7033
作者机构：
[蔡懿鑫; 孔祥峰; 蒋慧姣] 湖南农业大学动物科学技术学院,湖南省畜禽安全生产协同创新中心,湖南长沙410128;[蔡懿鑫; 孔祥峰; 蒋慧姣] 中国科学院亚热带农业生态研究所,动物营养生理与代谢过程湖南省重点实验室,湖南长沙410125;[贺建华] 湖南农业大学
关键词：
短链脂肪酸;生理功能;断奶应激;仔猪;肠道健康
摘要：
断奶应激会给养猪生产带来许多问题,抗生素是解决仔猪断奶应激问题的手段之一。长期使用抗生素会引起耐药菌产生、降低机体免疫力,故我国决定在2020年开始全面禁止抗生素在饲料中的使用。而短链脂肪酸是一种具有多种生理功能的添加剂,并且没有毒副作用,是一种绿色无污染的抗生素替代品,或将在养猪生产中起到重要作用。本文综述了短链脂肪酸在动物机体内的吸收代谢过程及其参与能量代谢、改善消化道微生态和提高机体免疫等生理功能,并介绍了部分短链脂肪酸在仔猪生产上的应用效果,旨在响应国家禁抗政策的同时,为生产中提高仔猪生长性能和替代抗生素的使用提供新思路。
语种：
中文
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Effect of resveratrol on growth performance, rectal temperature and serum parameters of yellow-feather broilers under heat stress
作者：
He, Shaoping;Li, Si;Arowolo, Muhammed Adebayo;Yu, Qifang;Chen, Fu;...
期刊：
Animal Science Journal ,2019年90(3):401-411 ISSN：1344-3941
通讯作者：
He, Jianhua
作者机构：
[Arowolo, Muhammed Adebayo; Chen, Fu; Yu, Qifang; He, Shaoping; Li, Si; He, Jianhua; Hu, Ruizhi] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.
通讯机构：
[He, Jianhua] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.
关键词：
heat stress;performance;resveratrol;serum parameter;yellow-feather broiler
摘要：
This study investigated the effect of dietary resveratrol supplementation on growth performance, rectal temperature, and serum parameters of yellow-feather broilers under heat stress. A total of 480 yellow-feather broilers (28-day-old) were randomly allotted to five groups with six replicates. A thermoneutral group (TN) (24 ± 2°C) received a basal diet and another four heat-stressed groups (37 ± 2°C for 8 hr/day and 24 ± 2°C for the remaining time) were fed the basal diet or basal diet with 200, 350, and 500 mg/kg resveratrol for 14 consecutive days. The results revealed that resveratrol supplementation improved average daily gain (p = 0.001), and decreased (p < 0.05) rectal temperature from d 3 when compared with heat-stressed group without resveratrol. In addition, supplementation with resveratrol at 350 or 500 mg/kg lowered (p < 0.05) the contents of corticosterone, adrenocorticotropic hormone, cholesterol, triglycerides, uric acid, malonaldehyde, and activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, increased (p < 0.05) the levels of triiodothyronine, the ratio of triiodothyronine to thyroxine, total protein, glutathione, and activities of alkaline phosphatase, total superoxide dismutase, catalase, and glutathione peroxidase, though with few fluctuation. In conclusion, supplementation with resveratrol can improve the growth performance by positively regulating serum metabolic parameters and alleviating tissue oxidant damage of broilers under heat stress. © 2019 Japanese Society of Animal Science
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英文
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The implication of lighting programmes in intensive broiler production system
作者：
Arowolo, M. A.;He, J. H.* ;He, S. P.;Adebowale, T. O.
期刊：
World's Poultry Science Journal ,2019年75(1):17-28 ISSN：0043-9339
通讯作者：
He, J. H.
作者机构：
[Arowolo, M. A.; He, S. P.; He, J. H.] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.;[Adebowale, T. O.] Univ Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China.
通讯机构：
[He, J. H.] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
关键词：
broiler;lighting regimen;photoperiod;production performance;scotoperiod
摘要：
The intensive production system for broiler chicken is characterised by the provision of a suitable micro-climatic condition such as temperature, airflow, relative humidity and light for proper bird's management which always, together with appropriate feeding and nutrition, favours the full growth and production potentials of the birds. Lighting, amongst other factors, is a potent and critical micro-climatic component in broiler houses as it influences many behavioural, physiological and metabolic processes in birds. To optimise the intensive system for broiler production, various lighting programmes (regarding light duration and its distribution, light colour/wavelength and light intensity) have been explored. This review compares the effects of different elements of lighting regimen on the growth performance, health, and welfare and carcass characteristics of broilers. Considering this, various degrees of intermittent photo-period (i.e. mixing photo- A nd scoto-periods within 24 hours) rather than one continuous photoperiod have been proven to significantly improve broilers' weight gain by 3.4-5.8%, feed to gain ratio up to 7.3%, mobility up to 46.5%, decrease mortality rate ranging between 0.43% and 0.72%, and finally, increase carcass yield. Short wavelength lights and light intensity of ≥5 lux after the initial brooding period are said to stimulate birds' metabolism and growth thereby, enhancing the production system. In conclusion, the lighting programme, apart from improving broiler productivity, could reduce cost expended on energy in an intensive production system. © 2018 World's Poultry Science Association.
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英文
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β-胡萝卜素的生理功能及其在母猪生产中的应用
作者：
安济山;胡睿智;杨玲;贺建华
期刊：
动物营养学报 ,2019年31(11):4933-4939 ISSN：1006-267X
作者机构：
湖南农业大学动物科学技术学院,长沙 410128;[安济山; 胡睿智; 杨玲; 贺建华] 湖南农业大学
关键词：
β-胡萝卜素;维生素A前体物;生物活性;母猪;繁殖性能
摘要：
β-胡萝卜素是类胡萝卜素中活性最高的维生素A前体物,不仅具有维生素A的生物活性,而且在动物繁殖方面发挥着独特的作用。母猪繁殖性能是母猪生产中的关键环节,β-胡萝卜素作为一种天然的饲料添加剂,在母猪生产中具有抗氧化、维持肠道健康、提高免疫力和繁殖性能等作用。本文阐述了β-胡萝卜素的生理功能及其作用机理,并综述了在母猪繁殖中应用β-胡萝卜素的研究成果,以期为β-胡萝卜素在母猪生产中更好的应用提供参考。
语种：
中文
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血根碱和牛膝多糖对肉鸡血液生化指标及免疫性能的影响
作者：
欧淑琦;刘祝英;郭丹;陈福;蔡懿鑫;...
期刊：
中国兽医学报 ,2019年39(10):2055-2060 ISSN：1005-4545
作者机构：
湖南农业大学动物科学技术学院;[郭丹] 北京中农弘科生物技术有限公司;[蔡懿鑫; 陈福; 刘祝英; 欧淑琦; 贺建华] 湖南农业大学
关键词：
肉鸡;血根碱;牛膝多糖;血液生化指标;免疫性能
摘要：
旨在研究血根碱和/或牛膝多糖对黄羽肉鸡血液生化指标及免疫性能的影响.试验选用1日龄(d)黄羽肉鸡300只,随机分成5个处理,每个处理6个重复,每个重复10只.试验分为两个阶段(1～28 d,28～56 d)进行.结果 显示,血根碱和/或牛膝多糖在一定程度上能够降低血液生化指标.1～28 d,血根碱和牛膝多糖对TC有显著的互作效应(P＜0.05).28～56 d,血根碱和牛膝多糖对血液生化指标无显著互作效应(P＞0.05);血根碱和牛膝多糖联合添加显著提高了脾小结直径和动脉周围淋巴鞘面积(P＜0.05),两者对脾小结直径没有显著互作效应(P＞0.05),对动脉周围淋巴鞘有极显著互作效应(P＜0.01).血根碱和牛膝多糖在一定程度上降低了NF-κB、ERK1/2的平均光密度,两者对NF-κB、ERK1/2在脾脏中表达无显著影响或无显著互作效应(P＞0.05).上述结果表明,血根碱和牛膝多糖有提高肉鸡免疫性能的作用,和抗生素效果相当.
语种：
中文
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Use of probiotics and botanical extracts to improve ruminant production in the tropics: A review
作者：
Arowolo, Muhammed A.;He, Jianhua*
期刊：
动物营养(英文) ,2018年4(3):241-249 ISSN：2405-6545
通讯作者：
He, Jianhua
作者机构：
[Arowolo, Muhammed A.; He, Jianhua] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[He, Jianhua] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
关键词：
Ruminant;Supplementation;Probiotics;Botanical extracts;Tropics
摘要：
Ruminant production, especially in the tropics and developing countries suffers a setback when compared with the temperate and developed countries, which is attributable to the kinds of available feed resources in the region of production. In the tropics, ruminants are restricted to grazing on low-quality forages, crop residues and agro-industrial by-products with very little or no concentrate diets, which adversely affect the animals in exhibiting their full production potential. Considering this fact, there is an increasing interest in improving the digestibility of these feed resources. In recent years, researchers have explored several methods to enhance the functions of rumen microflora, improve digestion and fermentation processes, as well as increase bioavailability and utilization of nutrients through feed supplementation. This review aims to explore the positive effects of supplementation of ruminant diets with probiotics or botanical extracts and their metabolites on the productivity of the animals. Moreover, the functions of these non-pathogenic and non-toxic live microorganisms (probiotics) and plant biologically active compounds (botanical extract) are explored because of the ban on non-therapeutic use of antibiotics as growth promoters coupled with the critical preference of consumers to high quality and safe animal products. It has been reported that these alternative supplemental products have a beneficial impact on both animal health and productivity, which is affecting stabilization of rumen environment, inhibition of pathogenic bacteria proliferation in gastro-intestinal tract, modulation of immune response, increase in fibre degradation and fermentation, nutrients availability and utilization, animal growth performance and milk production, among others. However, long-term in vivo studies are still required to determine the synergetic effects of these 2 safe supplemental products. © 2018 Chinese Association of Animal Science and Veterinary Medicine
语种：
英文
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Hepatic Sirt3 expression declines postpartum in dairy goats
作者：
Liu, Lei;Yao, Li;Peng, Tao;Wen, Lixin;Cai, Wenjie;...
期刊：
Journal of Dairy Research ,2018年85(2):163-166 ISSN：0022-0299
通讯作者：
Jia, Xinglin;He, Jianhua
作者机构：
[Jia, Xinglin; Peng, Tao; Wen, Lixin; Yao, Li; Liu, Lei] Hunan Agr Univ, Coll Vet Med, Hunan Collaborat Innovat Ctr Safety Prod Livestoc, Changsha 410128, Hunan, Peoples R China.;[Liu, Lei; He, Jianhua] Hunan Agr Univ, Coll Anim Sci, Changsha 410128, Hunan, Peoples R China.;[Cai, Wenjie] Hunan Inst Anim & Vet Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Jia, Xinglin; He, Jianhua] H;Hunan Agr Univ, Coll Vet Med, Hunan Collaborat Innovat Ctr Safety Prod Livestoc, Changsha 410128, Hunan, Peoples R China.;Hunan Agr Univ, Coll Anim Sci, Changsha 410128, Hunan, Peoples R China.
关键词：
Dairy;liver;oxidative stress;perinatal period;metabolic diseases
摘要：
The experiments reported in this research communication aimed to plot the expression pattern of Sirt3, a master regulator of energy metabolism and antioxidation defence, in the liver of dairy goats during perinatal period. Ten healthy dairy goats in late pregnancy were chosen, and needle biopsy was applied to collect liver samples at 1-week intervals. Protein levels of hepatic Sirt3 were analysed by western-blotting. Serum enzyme activities of manganese superoxide dismutase (Mn-SOD) and non-esterified fatty acids (NEFA) levels were measured, and their correlation with Sirt3 mRNA levels was also estimated. Compared with >3-week before parturition (BP), Sirt3 proteins were significantly reduced at 1-week after parturition (AP) and 2-week AP (P < 0·05), but increased on the day of parturition (P < 0·01). Correlation analysis revealed a positive association between hepatic Sirt3 mRNA levels and serum enzyme activity of Mn-SOD (r = 0·46), but a negative association between that and serum NEFA levels (r = -0·41). These data indicate that the decreased hepatic expression of Sirt3 might be one of the reasons that dairy goats undergo oxidative stress after parturition. Copyright © Hannah Dairy Research Foundation 2018.
语种：
英文
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血根碱的安全性、功能和应用概述
作者：
欧淑琦;夏嗣廷;胡睿智;廖波;蔡懿鑫;...
期刊：
饲料博览 ,2018年(7):44-48 ISSN：1001-0084
作者机构：
湖南农业大学动物科学技术学院,长沙,410128;[蔡懿鑫; 廖波; 胡睿智; 欧淑琦; 夏嗣廷; 贺建华] 湖南农业大学
关键词：
血根碱;安全性;功能;应用
摘要：
血根碱是一类具有极大开发前景的苯菲喹啉类生物碱,多用在医学领域,也可用于畜牧领域,血根碱作为饲料添加剂可以部分替代抗生素。文章对血根碱的安全性、杀菌、抑菌和杀虫作用,对肿瘤细胞的影响和对动物平滑肌的影响等生理功能及在生产中的应用作以概述。
语种：
中文
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Long-term Effects of Lysine Restriction on Liver Global Proteins, Meat Quality, and Blood Biochemical Parameters in Pigs
作者：
Liu, Zhaojin;Yuan, Yong;Yin, Jie;Li, Tiejun* ;Zhang, Hongfu;...
期刊：
PROTEIN AND PEPTIDE LETTERS ,2018年25(4):405-416 ISSN：0929-8665
通讯作者：
Li, Tiejun;He, Jianhua
作者机构：
[Liu, Zhaojin; Li, Tiejun; He, Jianhua; Yuan, Yong; Zhang, Hongfu] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.;[Yin, Jie; Li, Tiejun] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China.;[Zhang, Hongfu] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China.;[Liu, Zhaojin] Guangdong Haid Grp Co LTD, Guangzhou, Guangdong, Peoples R China.;[Liu, Zhaojin] Haid Cent Res Inst, Guangzhou, Guangdong, Peoples R China.
通讯机构：
[Li, TJ; He, JH] H;Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.
关键词：
Lysine;proteomics;biochemical parameters;meat quality;transporter;pig.
摘要：
Background: Our previous study suggested that short-term lysine restriction improved feed intake and gut microbiota in piglets. Thus, in this study, we further used proteomics technology to investigate the potential mechanism associated with long-term lysine restriction in pigs. In addition, blood biochemical parameters, meat quality, and muscle nutrient transporters were also evaluated in lysine restricted pigs. Results: The results showed that 131 proteins in the liver were markedly altered in response to dietary lysine restriction, with 54 being downregulated and 77 being upregulated, which mainly involved in neurodegenerative diseases, oxidative phosphorylation, and metabolic pathways. In addition, lysine restriction markedly reduced serum BUN, CHOL, and HDL abundances. Dietary lysine restriction enhanced meat color lightness and upregulated SLC7A2 expression. Conclusion: Lysine restriction affected meat quality, blood biochemical parameters, and liver global protein expressions. This study is the first attempt to evaluate the liver protein profile of lysine restricted pigs, and the current results may provide valuable information with respect to better understanding the host response to lysine restriction in pigs.
语种：
英文
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饲料中添加复合益生菌对断奶仔猪生长性能、粪便微生物及血液生化指标的影响
作者：
杨玲;欧阳富龙;袁旭鹏;李佳;赵玉蓉;...
期刊：
中国饲料 ,2018年(11):49-54 ISSN：1004-3314
作者机构：
[袁旭鹏; 欧阳富龙] 湖南农业大学动物科学技术学院,湖南长沙 410128;湖南畜禽安全生产协同创新中心,湖南长沙 410128;[袁旭鹏; 欧阳富龙] 湖南鑫广安农牧股份有限公司,湖南长沙 410128;广东大泽农生物科技股份有限公司,广东珠海,519031;[赵玉蓉; 杨玲; 贺建华] 湖南畜禽安全生产协同创新中心
关键词：
复合益生菌;丁酸梭菌;生长性能;菌群;断奶仔猪
摘要：
为探讨饲粮中添加含丁酸梭菌的复合益生菌对断奶仔猪饲粮中的抗生素替代效果,试验选取日龄基本一致,体重为(8.5±0.5)kg经过免疫的健康PIC断奶仔猪224头,随机分为4个组,每组4个重复,每个重复14头.对照组饲喂无抗饲粮;试验组分别用含丁酸梭菌的复合益生菌替代0%、50%、100%的抗生素(金霉素75 mg/kg+杆菌肽锌40 mg/kg+吉他霉素50 mg/kg).预试验4 d,正式试验25 d.结果表明:(1)各组生长性能均无显著差异(P>0.05),但随着益生菌的替代比例加大,腹泻率呈线性下降(P=0.04). (2)不同组间的碱性磷酸酶(ALP)、总蛋白(TP)及白蛋白(ALB)均无显著差异(P > 0.05),但血清尿素氮有显著差异(P < 0.05),50%替代组的血清尿氮素与比无抗组及100%替代组分别高出51.19%(P<0.05). (3)各组粪便微生物菌群结构有显著差异(P<0.05),与无抗组相比,100%替代组沙门氏菌降低了79.11%(P<0.01),50%替代组的产气荚膜菌降低94.29%(P<0.01).无抗组的大肠杆菌数量极显著高于其他组(P<0.01). (4)随着时间的推移,50%替代组及100%替代组的沙门氏菌、产气荚膜梭菌以及100%替代组的大肠杆菌持续下降,且差异极显著(P<0.01).利用复合益生菌替代50%的抗生素能有效减低料肉比,但可能增加肾负担.而100%替代抗生素其生长性能与抗生素组效果相当,而且能降低腹泻率.综上所述,在规模化养猪生产中,可以用丁酸梭菌复合益生菌替代抗生素的使用,且以100%替代效果更好.
语种：
中文
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丁酸梭菌的功能性研究进展及其在畜禽生产中的应用
作者：
杨玲;夏嗣廷;胡睿智;欧阳富龙;贺建华
期刊：
中国畜牧兽医 ,2018年(11):3077-3085 ISSN：1671-7236
作者机构：
湖南农业大学动物科学技术学院;[胡睿智; 杨玲; 夏嗣廷; 贺建华; 欧阳富龙] 湖南农业大学
关键词：
丁酸梭菌;肠道菌群;肠道屏障;抗氧化;免疫力
摘要：
丁酸梭菌(Clostridium butyricum)又名丁酸梭状芽孢杆菌、酪酸梭菌,是一种产丁酸、乳酸和乙酸的厌氧异养的革兰氏阳性芽孢杆菌,具有耐高温、耐酸和耐多种抗生素等生物学特性。丁酸梭菌定植于畜禽肠道,可抑制肠道有害菌的生长,同时促进有益菌的增殖,有效提高畜禽对营养物质的消化吸收及其抵抗力,进而提高畜禽养殖经济效益。丁酸梭菌存在于土壤或健康动物的粪便中,具有绿色、无残留、安全性好,以及稳定性及耐药性强等特点,是一种具有广泛开发潜力的绿色添加剂。作者主要介绍了丁酸梭菌的特性,简述了其对畜禽肠道形态、肠道屏障、肠道菌群、免疫等方面的影响,回顾了近十年来丁酸梭菌在畜禽生产中的应用进展,并探讨了其在生产应用中的问题,以期为丁酸梭菌的进一步应用提供理论依据。
语种：
中文
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