期刊论文

Li, Xiaobing;Li, Xinwei

英文

FRONTIERS IN IMMUNOLOGY

1664-3224

2018

9

MAR

467

10.3389/fimmu.2018.00467

This work was supported by the National key research and development program (Beijing, China; grant no. 2016YFD0501007-3 and 2016YFD0501206) and National Natural Science Foundation of China (Beijing, China; grant nos. 31572581, 31472247, 31402265, 31372494, and 31772810)

本校为其他机构

Dairy cows with ketosis displayed lipid metabolic disorder and high inflammatory levels. Adipose tissue is an active lipid metabolism and endocrine tissue and is closely related to lipid metabolism homeostasis and inflammation. Perilipin 1 (PLIN1), an adipocyte-specific lipid-coated protein, may be involved in the above physiological function. The aim of this study is to investigate the role of PLIN1 in lipid metabolism regulation and inflammatory factor synthesis in cow adipocytes. The results showed that PLIN1 overexpression upregulated the e...