期刊论文

Tan, Zhuliang;Yi, Jine

英文

Biomedicine & Pharmacotherapy

0753-3322

2020

121

109554

10.1016/j.biopha.2019.109554

We are grateful for the financial support from the Education Department of Hunan Province, China ( 17A098 and 17B125 ), Hunan Provincial Innovation Foundation for Postgraduate, China ( CX2018B411 ), Natural Science Foundation of Hunan Province, China ( 2015JJ2077 ) and Innovation and Entrepreneurship Investment Project in Hunan Province, China ( 2017GK5009 ).

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gamma-Oryzanol, a mixture of ferulic acid esters of plant sterols and triterpene alcohols existed in rice bran oil, can ameliorate lipid metabolism and enhance antioxidant activity. In this study, we used hydrogen peroxide (H2O2)-induced injury in human hepatic L02 cells to investigate the mechanisms involved in the hepatoprotective activity of gamma-oryzanol. The injuries produced by H2O2 in L02 cells include increased levels of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS), decreased activities of superoxide dismutase (SOD) and catalase (CAT), loss of mitochondrial me...