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Psepssm-based prediction for the protein-atp binding sites

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成果类型:
期刊论文
作者:
Li Qian;Yu Jiang;Yan YuXuan;Chen Yuan;Tan SiQiao
通讯作者:
Siqiao, T.
作者机构:
[Li Qian; Yan YuXuan; Tan SiQiao] Hunan Engn Res Ctr Rural & Agr Informationizat, Changsha 410128, Peoples R China.
[Li Qian; Yan YuXuan; Tan SiQiao] Hunan Agr Univ, Coll Informat & Intelligence, Changsha 410128, Peoples R China.
[Chen Yuan; Yu Jiang] Hunan Agr Univ, Hunan Engn & Technol Res Ctr Agr Big Data Anal &, Changsha 410128, Peoples R China.
通讯机构:
[Siqiao, T.] D
Department of Bioinformatics, China
语种:
英文
关键词:
Protein-ATP binding site prediction;evolution information;PsePSSM;unbalanced dataset;SVC;featureextraction.
期刊:
CURRENT BIOINFORMATICS
ISSN:
1574-8936
年:
2021
卷:
16
期:
4
页码:
576-582
基金类别:
This work is sponsored by the grant from the National Natural Science Foundation (31772157) and the science research projects of the Hunan Provincial Department of Education (17A096), China.
机构署名:
本校为其他机构
摘要:
Background: Predicting the protein-ATP binding sites is a highly unbalanced binary classi-fication problem, and higher precision prediction through the machine learning methods is of great sig-nificance to the researches on proteins’ functions and the design of drugs. Objective: Most existing researches typically select 17aa as the length of window by experience, and extract features by the Position-specific Scoring Matrix (PSSM), and then construct models predicting with SVC. However, the independent prediction values obtained in these resear...

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