Lactobacillus fermentum ZC529 Protects Intestinal Epithelial Barrier Integrity by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yuan, Zian;Huang, Lang;Hu, Zhenguo;Deng, Junhao;Duan, Yehui;...

通讯作者：

Chen Zhang<&wdkj&>Xiongzhuo Tang

作者机构：

These authors contributed equally to this work.

Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Yuelushan Laboratory, Changsha 410128, China

Faculty of Agriculture, Kagoshima University, Korimoto, Kagoshima 8900065, Japan

Authors to whom correspondence should be addressed.

通讯机构：

[Chen Zhang; Xiongzhuo Tang] A

Authors to whom correspondence should be addressed.<&wdkj&>Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Yuelushan Laboratory, Changsha 410128, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Institute of Yunnan Circular Agricultural Industry, Pu’er 665000, China<&wdkj&>Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230011, China

语种：

英文

关键词：

Lactobacillus fermentum;NF-κB;Nrf2;anti-inflammation;antioxidant

期刊：

Antioxidants

ISSN：

2076-3921

年：

2025

卷：

期：

页码：

732-

DOI：

10.3390/antiox14060732

基金类别：

Conceptualization, C.Z. and X.T.; data curation, L.H. and Z.H.; formal analysis, L.H. and J.D.; funding acquisition, Q.J., B.T., C.Z. and X.T.; investigation, Z.Y., L.H. and Z.H.; methodology, Z.Y., Z.H., Y.D. and C.Z.; project administration, B.T. and X.T.; resources, Y.D., Q.J., B.T. and X.M.; software, Z.Y., Q.J. and X.M.; supervision, B.T. and X.M.; validation, Z.H. and J.D.; visualization, L.H. and J.D.; writing—original draft, Z.Y. and L.H.; writing—review and editing, C.Z. and X.T. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Natural Science Foundation of China (32130099, 32072745), Science and Technology Major Project of Yunnan Province (202202AE090032), Natural Science Foundation of Hunan Province (2024JJ1004), and Hunan Provincial Department of Education Scientific Research Project (23B0222, 23B0220).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

The probiotic bacteria Lactobacillus fermentum ZC529 (L.f ZC529) has been identified from the colon of the Diannan small-ear (DSE) pig, but its intestinal protective function still lacks investigation. Here, we established a dextran sodium sulfate (DSS)-induced intestinal oxidative stress model in both Drosophila and porcine small intestinal epithelial (IPEC-J2) cell lines to explore the anti-oxidative and anti-inflammatory effects of L.f ZC529. The data showed that the intestinal colonization of L.f ZC529 counteracted DSS-induced intestinal ox...

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Lactobacillus fermentum ZC529 Protects Intestinal Epithelial Barrier Integrity by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway

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