Lactobacillus delbrueckii Interfere With Bile Acid Enterohepatic Circulation to Regulate Cholesterol Metabolism of Growing-Finishing Pigs via Its Bile Salt Hydrolase Activity

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成果类型：

期刊论文

作者：

Hou, Gaifeng;Peng, Wei;Wei, Liangkai;Li, Rui*;Yuan, Yong;...

通讯作者：

Li, Rui;Huang, Xingguo

作者机构：

[Wei, Liangkai; Hou, Gaifeng; Li, Rui; Huang, Xingguo; Li, R; Huang, XG; Peng, Wei; Yuan, Yong; Yin, Yulong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China.

[Wei, Liangkai; Hou, Gaifeng; Li, Rui; Huang, Xingguo; Li, R; Huang, XG; Peng, Wei; Yuan, Yong; Yin, Yulong] Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Peoples R China.

[Li, Rui; Yin, Yulong] Chinese Acad Sci, Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Inst Subtrop Agr,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Changsha, Peoples R China.

通讯机构：

[Li, R; Huang, XG] H

[Li, Rui] C

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China.

Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Peoples R China.

Chinese Acad Sci, Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Inst Subtrop Agr,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Changsha, Peoples R China.

语种：

英文

关键词：

： Lactobacillus delbrueckii;ieal microbiota;Cholesterol;Bile acids;Enterohepatic Circulation;pigs 2

期刊：

FRONTIERS IN NUTRITION

ISSN：

2296-861X

年：

2020

卷：

页码：

617676

DOI：

10.3389/fnut.2020.617676

基金类别：

This research was supported by the National Natural Science Foundation of China (Grant nos. 31772617 and 31802074), the Hunan Excellent Post-doctoral Innovative Talents Project (Grant no. 2020RC2063), the Hunan postgraduate research and innovation project (Grant nos. CX2017B346 and CX2018B399), and the School-enterprise cooperation project (E0490205 and E0490207).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Microbiota-targeted therapies for hypercholesterolemia get more and more attention and are recognized as an effective strategy for preventing and treating cardiovascular disease. The experiment was conducted to investigate the cholesterol-lowering mechanism of Lactobacillus delbrueckii in a pig model. Twelve barrows (38.70 ± 5.33 kg) were randomly allocated to two groups and fed corn–soybean meal diets with either 0% (Con) or 0.1% Lactobacillus delbrueckii (Con + LD) for 28 days. L. delbrueckii–fed pigs had lower serum contents of total chol...

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Lactobacillus delbrueckii Interfere With Bile Acid Enterohepatic Circulation to Regulate Cholesterol Metabolism of Growing-Finishing Pigs via Its Bile Salt Hydrolase Activity

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