Lactobacillus delbrueckii protected intestinal integrity, alleviated intestinal oxidative damage, and activated toll-like receptor–bruton’s tyrosine kinase–nuclear factor erythroid 2-related factor 2 pathway in weaned piglets challenged with lipopolysaccharide

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成果类型：

期刊论文

作者：

Chen, Fengming;Chen, Jiayi;Chen, Qinghua;Yang, Lingyuan;Yin, Jie;...

通讯作者：

Li, Y.;Huang, X.

作者机构：

[Li, Yinghui; Chen, Jiayi; Yang, Lingyuan; Yin, Jie; Chen, Fengming; Chen, Qinghua; Huang, Xingguo] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

[Li, Yinghui; Chen, Jiayi; Yang, Lingyuan; Yin, Jie; Chen, Fengming; Chen, Qinghua; Huang, Xingguo] CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.

[Li, Yinghui; Chen, Jiayi; Yang, Lingyuan; Yin, Jie; Chen, Fengming; Chen, Qinghua; Huang, Xingguo] Hunan Agr Univ, Engn Res Ctr Feed Safety & Efficient Utilizat, Educ Minist, Changsha 410128, Peoples R China.

通讯机构：

[Li, Y.; Huang, X.] C

[Li, Y.; Huang, X.] H

[Li, Y.; Huang, X.] T

Hunan Co-Innovation Center of Animal Production Safety, China

College of Animal Science and Technology, China

语种：

英文

关键词：

Lactobacillus delbrueckii;intestinal integrity;oxidative stress;TLR–Btk–Nrf2;weaned piglets;LPS

期刊：

Antioxidants

ISSN：

2076-3921

年：

2021

卷：

期：

页码：

1-16

DOI：

10.3390/antiox10030468

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772617, 31802074, U20A2055]

机构署名：

本校为第一机构

院系归属：

动物科学技术学院

摘要：

Oxidative stress is increasingly being recognized as a player in the pathogenesis of intestinal pathologies, and probiotics are becoming an attractive means of addressing it. The present study investigated the effects of dietary supplementation with Lactobacillus delbrueckii (LAB) on intestinal integrity and oxidative damage in lipopolysaccharide (LPS)-challenged piglets. A total of 36 crossbred weaned piglets (Duroc × Landrace × Large Yorkshire) were randomly divided into three groups: (1) non-challenged controls (CON), (2) LPS-challenged co...

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Lactobacillus delbrueckii protected intestinal integrity, alleviated intestinal oxidative damage, and activated toll-like receptor–bruton’s tyrosine kinase–nuclear factor erythroid 2-related factor 2 pathway in weaned piglets challenged with lipopolysaccharide

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