Lactobacillus delbrueckii alleviates lipopolysaccharide-induced muscle inflammation and atrophy in weaned piglets associated with inhibition of endoplasmic reticulum stress and protein degradation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhong, Songshi;Sun, Zhiyuan;Tian, Qiyu;Wen, Wei;Chen, Fengming;...

通讯作者：

Huang, Xingguo;Li, YH

作者机构：

[Li, Yinghui; Tian, Qiyu; Li, YH; Zhong, Songshi; Huang, Xingguo; Huang, XG; Wen, Wei] Hunan Agr Univ, Coll Anim Sci & Technol, 1 Nongda Rd, Changsha 410128, Peoples R China.

[Sun, Zhiyuan] China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China.

[Li, Yinghui; Tian, Qiyu; Huang, Xingguo] Hunan Engn Res Ctr Poultry Prod Safety, Changsha, Peoples R China.

[Li, Yinghui; Tian, Qiyu; Huang, Xingguo] Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Peoples R China.

[Chen, Fengming] Changsha Med Univ, Hunan Prov Key Lab TCM Agr Biogenom, Changsha, Peoples R China.

通讯机构：

[Li, YH ; Huang, XG] H

Hunan Agr Univ, Coll Anim Sci & Technol, 1 Nongda Rd, Changsha 410128, Peoples R China.

语种：

英文

关键词：

endoplasmic reticulum stress;Lactobacillus delbrueckii;muscle inflammation;protein degradation;weaned piglets

期刊：

FASEB JOURNAL

ISSN：

0892-6638

年：

2024

卷：

期：

页码：

e70041-

DOI：

10.1096/fj.202400969RR

基金类别：

Natural Science Foundation of Hunan Province ((sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic))

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Anti‐inflammatory effect of Lactobacillus delbrueckii supply on muscle atrophy of piglets could be likely regulated by inhibiting secretion of pro‐inflammatory cytokines IL‐6 and TNF‐α through inactivation of the ER stress/NF‐κB singling pathway, along with reduction in protein degradation by inhibition of the ubiquitin‐proteasome and autophagy‐lysosome systems. Abstract Pro‐inflammatory cytokines in muscle play a pivotal role in physiological responses and in the pathophysiology of inflammatory disease and muscle atrophy. Lactobacill...

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Lactobacillus delbrueckii alleviates lipopolysaccharide-induced muscle inflammation and atrophy in weaned piglets associated with inhibition of endoplasmic reticulum stress and protein degradation

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