l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

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成果类型：

期刊论文

作者：

Lin, Ling;Han, Shumin;Gong, Zhihua;Ding, Furong;Liu, Zhonghua*;...

通讯作者：

Liu, Zhonghua;Xiao, WJ

作者机构：

[Han, Shumin; Gong, Zhihua; Liu, Zhonghua; Xiao, Wenjun; Xiao, WJ; Lin, Ling] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

[Han, Shumin; Gong, Zhihua; Liu, Zhonghua; Xiao, Wenjun; Xiao, WJ; Lin, Ling] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

[Han, Shumin; Gong, Zhihua; Liu, Zhonghua; Xiao, Wenjun; Xiao, WJ; Lin, Ling] Hunan Agr Univ, Coinnovat Ctr, Educ Minist Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

[Ding, Furong] Agr & Rural Bur Shimen Cty, Changde 415300, Hunan, Peoples R China.

通讯机构：

[Liu, ZH; Xiao, WJ ] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Coinnovat Ctr, Educ Minist Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

6172-6186

DOI：

10.1039/d3fo01001e

基金类别：

This work was supported by the National Key Research and Development Program of China (No. 2022YFD1600800) and the Major Science and Technology Project of Hunan Province (No. 2021NK1020).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Extreme heat caused by global warming accelerated the frequency of heat stress (HS). Proteotoxic stress induced by the aggregation of misfolded proteins and metabolic stress triggered by alterations in the metabolism were observed during HS. The activation of heat shock factor 1 (Hsf1) and its interaction with adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) are critical in addressing proteotoxicity and metabolic stress in heat-stressed organisms. Previous studies have shown that l-theanine (LTA) can regulate nutrient metabolis...

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l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

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