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Chlorogenic Acid Functions as a Novel Agonist of PPAR γ 2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

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成果类型:
期刊论文
作者:
Peng, Shu-guang;Pang, Yi-lin;Zhu, Qi;Kang, Jing-he;Liu, Ming-xin;...
通讯作者:
Wang, Zheng
作者机构:
[Liu, Ming-xin; Wang, Zheng; Pang, Yi-lin; Peng, Shu-guang; Zhu, Qi] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
[Peng, Shu-guang] Res Inst Hunan Tobacco Sci, Changsha 410007, Hunan, Peoples R China.
[Peng, Shu-guang] Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China.
[Kang, Jing-he] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop, Changsha 410125, Hunan, Peoples R China.
通讯机构:
[Wang, Zheng] H
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
语种:
英文
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2018
卷:
2018
页码:
8594767
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31071531]; Foundation of the Research Institute of Hunan Tobacco Science [15-17Aa04]
机构署名:
本校为第一且通讯机构
院系归属:
植物保护学院
生物科学技术学院
摘要:
Rosiglitazone (RG) is a well-known activator of peroxisome proliferator-activated receptor-gamma (PPARγ) and used to treat hyperglycemia and type 2 diabetes; however, its clinical application has been confounded by adverse side effects. Here, we assessed the roles of chlorogenic acid (CGA), a phenolic secondary metabolite found in many fruits and vegetables, on the differentiation and lipolysis of mouse 3T3-L1 preadipocytes. The results showed that CGA promoted differentiation in vitro according to oil red O staining and quantitative polymeras...

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