Single-cell transcriptomics and tissue metabolomics uncover mechanisms underlying wooden breast disease in broilers

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成果类型：

期刊论文

作者：

Zhao, Di;Song, Zehe;Shen, Li;Xia, Tian;Ouyang, Qingyuan;...

通讯作者：

Kang, KL

作者机构：

[Song, Zehe; He, Xi; Ouyang, Qingyuan; Kang, Kelang; Zhao, Di; Zhang, Haihan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

[Song, Zehe; He, Xi; Ouyang, Qingyuan; Kang, Kelang; Zhao, Di; Zhang, Haihan] Hunan Engn Res Ctr Poultry Prod Safety, Changsha 410128, Peoples R China.

[Song, Zehe; He, Xi; Ouyang, Qingyuan; Zhao, Di; Zhang, Haihan] Yuelushan Lab, Changsha 410128, Peoples R China.

[Kang, Kelang] Hunan Acad Agr Sci, Changsha 410128, Peoples R China.

[Shen, Li; Xia, Tian] Shanghai Personal Biotechnol Co Ltd, Shanghai 200030, Peoples R China.

通讯机构：

[Kang, KL ] H

Hunan Agr Univ, 1 Nongda Rd, Changsha 410128, Hunan Province, Peoples R China.

语种：

英文

关键词：

Chicken;Metabolome;Single-cell transcriptome;Wooden breast

期刊：

POULTRY SCIENCE

ISSN：

0032-5791

年：

2024

卷：

103

期：

页码：

104433

DOI：

10.1016/j.psj.2024.104433

基金类别：

National Natural Science Foundation of China [U21A201287]; Hunan Poultry Industry Technology System

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Accompanied by the accelerated growth rate of chickens, the quality of chicken meat has deteriorated in recent years. Wooden breast (WB) is a severe myopathy affecting meat quality, and its pathophysiology depends on gene expression and intercellular interactions of various cell types, which are not yet fully understood. We have performed a comprehensive transcriptomic and metabolomic atlas of chicken WB muscle. Our data showed a significant increase in the number of immune cells, WB muscle displayed a unique cluster of macrophages (cluster 11), distinct from the M1 and M2 macrophages. Regardi...

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Single-cell transcriptomics and tissue metabolomics uncover mechanisms underlying wooden breast disease in broilers

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