Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress

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成果类型：

期刊论文

作者：

Li, Yuanyuan;Zhang, Qike;Liu, Xiaofang;Wang, Yongkang;Yang, Chenglin;...

通讯作者：

Yuan, ZH;Liang, ZEN

作者机构：

[Liu, Xiaofang; Li, Yuanyuan; Yi, Jine; Wu, You; Xiao, Bo; Yuan, Zhihang; Wang, Yongkang; Wu, Jing; Yang, Chenglin; Wu, Aoao; Zhang, Qike; Feng, Yiya] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Yuan, Zhihang; Wu, Jing] Inst Yunnan Circular Agr Ind, Puer 665000, Peoples R China.

[Liang, Zengenni; Liang, ZEN] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Dongting Lab, Hunan Prov Key Lab Fruits & Vegetables Storage Pro, Changsha 410125, Peoples R China.

[Liang, Zengenni; Liang, ZEN] Yulushan Lab, Changsha 410128, Peoples R China.

通讯机构：

[Yuan, ZH ; Liang, ZEN ] H

Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

Inst Yunnan Circular Agr Ind, Puer 665000, Peoples R China.

Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Dongting Lab, Hunan Prov Key Lab Fruits & Vegetables Storage Pro, Changsha 410125, Peoples R China.

Yulushan Lab, Changsha 410128, Peoples R China.

语种：

英文

关键词：

IP3R1–GRP75–VDAC1 complex;MAM;citrinin;intestinal;mitochondrial oxidative stress;pyroptosis

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2025

卷：

期：

页码：

5803–5815

DOI：

10.1021/acs.jafc.4c11218

基金类别：

Hunan Natural Science Foundation [2023JJ30301]; Scientific Research Project of Hunan Provincial Department of Education [21B0218]; Hunan Agricultural University Graduate Student Research and Innovation Program [2024XKC026]; Science and Technology Major Project of Yunnan Province [202202AE090032]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Citrinin (CTN) is commonly found in animal feed and stored grains and poses a serious threat to human and animal health. Formation of the IP3R1-GRP75-VDAC1 complex has been shown to play a key role in intestinal defense against harmful stimuli, but the mechanism of its action in CTN-exposure-induced enterotoxicity is not clear. Therefore, the aim of this study was to investigate the role of the IP3R1-GRP75-VDAC1 complex in CTN-exposure-induced intestinal and IPEC-J2 monolayer cell damage in mice. It was shown that CTN exposure triggered intestinal cell pyroptosis and increased IP3R1-GRP75-VDAC...

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Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress

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