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Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium

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成果类型:
期刊论文
作者:
Ge Zhang;Yue-hui Ma;Yuan-yue Zhang;Wei-jun Guan;Qian-jun Zhao;...
通讯作者:
Jian-lin Han
作者机构:
[Guan W.; Zhao H.; Zhang G.; Ma Y.; Zhao Q.] Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
[Zhang Y.] Department of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya
CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
[Han J.] Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya, CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
通讯机构:
[Han, J.] K
Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, , Beijing 100193, China
语种:
英文
关键词:
Sheep;DSG4 gene;single-strand conformational polymorphism (SSCP);variation;linkage disequilibrium
期刊:
African Journal of Biotechnology
ISSN:
1684-5315
年:
2011
卷:
10
期:
36
页码:
6852-6856
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Desmoglein 4 (DSG4) plays an important role in the regulation of growth and differentiation of hair follicles in mammals. In this study, a 755 bp long segment of DSG4 was screened in 544 sheep sampled from nine Chinese indigenous breeds and two Western breeds using PCR-SSCP assay with three different pairs of primers. Two of the three fragments showed polymorphisms with genotypes defined as AA, AB, BB and BC, and DD, DE, and EE, respectively. Interestingly, polymorphisms in these two fragments were in strong linkage disequilibrium. Only three h...

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