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Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium

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成果类型:
期刊论文
作者:
Zhang, Ge;Ma, Yue-hui;Zhang, Yuan-yue;Guan, Wei-jun;Zhao, Qian-jun;...
通讯作者:
Han, Jian-lin
作者机构:
[Han, Jian-lin; Zhang, Ge; Guan, Wei-jun; Zhao, Hui-jing; Zhao, Qian-jun; Ma, Yue-hui] Chinese Acad Agr Sci, Key Lab Farm Anim Genet Resources & Utilizat, Minist Agr, Inst Anim Sci, Beijing 100193, Peoples R China.
[Zhang, Yuan-yue] Hunan Agr Univ, Dept Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Han, Jian-lin] ILRI, Nairobi 00100, Kenya.
[Han, Jian-lin] Chinese Acad Agr Sci, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Reso, Beijing 100193, Peoples R China.
通讯机构:
[Han, Jian-lin] C
Chinese Acad Agr Sci, Key Lab Farm Anim Genet Resources & Utilizat, Minist Agr, Inst Anim Sci, Beijing 100193, Peoples R China.
语种:
英文
关键词:
Sheep;DSG4 gene;single-strand conformational polymorphism (SSCP);variation;linkage disequilibrium
期刊:
African Journal of Biotechnology
ISSN:
1684-5315
年:
2011
卷:
10
期:
36
页码:
6852-6856
基金类别:
National Key Project of Scientific and Technical Supporting Programs; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2008BADB2B01]; National Special Construction Fund of Modern Agricultural Industrial Technology System [nycytx-40-5]; National GMO Cultivation Major Project of New Varieties [2008ZX08009-003]
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Desmoglein 4 (DSG4) plays an important role in the regulation of growth and differentiation of hair follicles in mammals. In this study, a 755 bp long segment of DSG4 was screened in 544 sheep sampled from nine Chinese indigenous breeds and two Western breeds using PCR-SSCP assay with three different pairs of primers. Two of the three fragments showed polymorphisms with genotypes defined as AA, AB, BB and BC, and DD, DE, and EE, respectively. Interestingly, polymorphisms in these two fragments were in strong linkage disequilibrium. Only three haplotypes were found, of which haplotype AD determ...

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