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From probiotic chassis to modification strategies, control and improvement of genetically engineered probiotics for inflammatory bowel disease

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成果类型:
期刊论文
作者:
Huang, Yuewen;Peng, Shan;Zeng, Rong;Yao, Hao;Feng, Guangfu*;...
通讯作者:
Feng, Guangfu;Fang, J
作者机构:
[Feng, Guangfu; Peng, Shan; Feng, GF; Huang, Yuewen; Zeng, Rong; Fang, Jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Yao, Hao] Changsha IMADEK Intelligent Technol Co LTD, Changsha 410081, Peoples R China.
通讯机构:
[Feng, GF; Fang, J ] H
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
语种:
英文
关键词:
Genetically engineered probiotic;Gut microbiota;Inflammatory bowel disease (IBD);Inflammatory factor;Intestinal barrier;Therapeutic protein
期刊:
Microbiological research
ISSN:
0944-5013
年:
2024
卷:
289
页码:
127928
基金类别:
Science and Technology Innovation Program of Hunan Province [2023RC3148]; Opening Foundation of the State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University [20230754]; Scientific Research Foundation of Hunan Provincial Education Department [22B0221]; National Natural Science Foundation of China [22004035, 31672457]; National Key Research and Development Program [2021YFD1300205-2]; Double first-class construction project of Hunan Agricultural University [CX20190497]
机构署名:
本校为第一且通讯机构
院系归属:
生物科学技术学院
摘要:
With the rising morbidity of inflammatory bowel disease (IBD) year by year, conventional therapeutic drugs with systemic side effects are no longer able to meet the requirements of patients. Probiotics can improve gut microbiota, enhance intestinal barrier function, and regulate mucosal immunity, making them a potential complementary or alternative therapy for IBD. To compensate for the low potency of probiotics, genetic engineering technology has been widely used to improve their therapeutic function. In this review, we systematically summarize the genetically engineered probiotics used for I...

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