Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

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成果类型：

期刊论文

作者：

Qin, Si;Deng, Fangming;Wu, Weiguo;Jiang, Liwen;Yamashiro, Takaaki;...

通讯作者：

Hou, De-Xing

作者机构：

[Deng, Fangming; Wu, Weiguo; Qin, Si; Hou, De-Xing; Jiang, Liwen] Hunan Agr Univ, Coll Food Sci & Technol, Key Lab Food Sci & Biotechnol Hunan Prov, Changsha, Hunan, Peoples R China.

[Yamashiro, Takaaki; Qin, Si; Hou, De-Xing; Yano, Satoshi] Kagoshima Univ, Fac Agr, Dept Biochem Sci & Technol, Kagoshima 8900065, Japan.

[Hou, De-Xing] Kagoshima Univ, United Grad Sch Agr Sci, Kagoshima 8900065, Japan.

[Hou, De-Xing] Kagoshima Univ, Fac Agr, Dept Biochem Sci & Technol, Korimoto 1-21-24, Kagoshima 8900065, Japan.

通讯机构：

[Hou, De-Xing] K

Kagoshima Univ, Fac Agr, Dept Biochem Sci & Technol, Korimoto 1-21-24, Kagoshima 8900065, Japan.

语种：

英文

关键词：

Baicalein;Keap1 modification;Nrf2 ubiquitination;Nrf2/Keap1 system

期刊：

Archives of Biochemistry and Biophysics

ISSN：

0003-9861

年：

2014

卷：

559

页码：

53-61

DOI：

10.1016/j.abb.2014.03.011

基金类别：

This work was partially supported by National Natural Science Foundation of China ( 31101268 ) and Scientific Research Fund of Hunan Provincial Education Department ( 13B047 ) to S. Qin, and by Hunan Agriculture University Grant for 100 Intelligent Projects, and the fund of Scholar Research of Kagoshima University, Japan to D.X. Hou.

机构署名：

本校为第一机构

院系归属：

食品科学技术学院

摘要：

Baicalein, a major component of Scutellaria baicalensis Georgi (Huang Qin), is widely used in the traditional Chinese medicine. However, the mechanisms underlying cancer chemoprevention are still not clear. The present study aimed to clarify how baicalein modulate Nrf2/Keap1 system to exert its cytoprotection and cancer chemoprevention. In the upstream cellular signaling, baicalein stimulated the phosphorylation of MEK1/2, AKT and JNK1/2, which were demonstrated to be essential for baicalein-induced Nrf2 expression by their inhibitors. Immunopr...

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Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

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