期刊论文

Protective effects of active compound from Phyllanthus urinaria L.on CCl4-induced hepatic inj ury in mice

中文

江苏建筑职业技术学院学报

2095-3550

2016

16

3

27-31

10.3969/j.issn.2095-3550.2016.03.007

湖南省教育厅青年基金:抗乙肝药叶下珠活性成分提取及指纹图谱研究（04B018）； 衡阳市科技局应用基础研究计划项目:叶下珠抗乙肝病毒有效成分的研究（2007KJ014）；

本校为其他机构

将60只昆明小鼠随机分成正常对照组,模型组,100、200、400 mg/kg PE组和200 mg/kg联苯双酯阳性对照组共6组,采用50 mL/kg四氯化碳（CCl4）灌胃给药,连续给药7 d,制备小鼠化学性肝损伤模型,检测血清ALT、AST、TP、ALB的水平及肝组织匀浆液SOD活性和MDA的含量,并计算出肝指数及A/G,观察病理肝脏的损伤程度。实验结果表明：叶下珠提取物能显著减弱肝损伤小鼠血清ALT、AST水平的升高,提高血清ALB的合成量及A/G值,提高肝组织SOD活力,降低MDA生成量,使肝细胞变性、炎症细胞浸润等病变程度减轻。由此充分证明叶下珠提取物提取物有显著的保肝护肝作用。

Sixty Kuming mice were randomly divided into six groups including a normal control group,a model group,three PE-treatment groups at doses of 100mg/kg,200mg/kg and 400 mg/kg of PE re-spectively,and a positive control group treated with 200 mg/kg of dimethyl dicarboxylate biphenyl （DDB）,1 0 mice in each group.Two hours after the 7 d administration with PE the mice in PE groups were treated with 50mL/kg CCl4 to establish hepatic injury model of mice.Then the levels of alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total protei...