Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method

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成果类型：

期刊论文

作者：

Zhang, Yifan;Liu, Jianfeng;Basang, Zhuoma;Yang, Qianxun;Chen, Hongce;...

通讯作者：

Jin, X;Jin, Xin;Wang, YY

作者机构：

[Liu, Huanhuan; Jin, Xin; Zhang, Yifan; Jin, X] BGI Res, Chongqing, Peoples R China.

[Wang, Yingying; Jin, Xin; Yang, Qianxun; Chen, Hongce; Zhang, Yifan; Jin, X; Chen, Shuo] BGI Res, Shenzhen, Peoples R China.

[Zhang, Yifan] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.

[Wang, Yingying; Jin, Xin; Zhang, Yifan; Jin, X] BGI Res, Shenzhen Key Lab Trans Biotechnol, Shenzhen, Peoples R China.

[Liu, Jianfeng] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Neurol, Shenzhen, Peoples R China.

通讯机构：

[Jin, X; Jin, X ; Wang, YY ] B

BGI Res, Chongqing, Peoples R China.

BGI Res, Shenzhen, Peoples R China.

BGI Res, Shenzhen Key Lab Trans Biotechnol, Shenzhen, Peoples R China.

BGI Res, State Key Lab Genome & Multiomics Technol, Shenzhen, Peoples R China.

语种：

英文

关键词：

disease profile;hypoxia-ischemia;omics;risk assessment;shared features

期刊：

Frontiers in Genetics

ISSN：

1664-8021

年：

2025

卷：

页码：

1587854

DOI：

10.3389/fgene.2025.1587854

基金类别：

National Key R&D Program of China [2022YFC2502402]; Shenzhen Medical Research Fund [B2404004]; Science and Technology Program of Xizang Autonomous Region [XZ202303ZY0008G]; National Natural Science Foundation of China [82241023]

机构署名：

本校为其他机构

院系归属：

植物保护学院

摘要：

The hypoxia-ischemia (H-I) diseases share some common mechanisms which may help to delay the diseases' processing. However, the shared features are still unclear due to the lack of large scale high-quality multi - omics data that specifically target the same disease, population, and tissues/cells. In this study, we developed a novel risk assessment method to analyze four H-I diseases including eclampsia/preeclampsia (PE), pulmonary arterial hypertension (PAH), high-altitude polycythemia (HAPC), and ischemic stroke (IS). A combined new evaluation score was designed to integrate evaluation infor...

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Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method

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