Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats.

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期刊论文

作者：

Yang, Zhe;Zhu, Ming-zhi;Zhang, Yang-bo;Wen, Bei-bei;An, Hui-min;...

通讯作者：

Liu, Zhong-hua

作者机构：

[Zhu, Ming-zhi; Liu, Zhong-hua; Wen, Bei-bei; Yang, Zhe; Ou, Xing-chang] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha, Hunan, Peoples R China.

[Zhang, Yang-bo; Lin, Hai-yan; Liu, Zhong-hua; Yang, Zhe; An, Hui-min; Xiong, Yi-fan] Hunan Agr Univ, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha, Hunan, Peoples R China.

[Huang, Jian-an; Liu, Zhong-hua; Yang, Zhe; Xiong, Yi-fan] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha, Hunan, Peoples R China.

[Liu, Zhong-hua] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Dept Hort & Landscape, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, Zhong-hua] H

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Dept Hort & Landscape, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

caffeine;EGCG;epigallocatechin-3-gallate;green tea;nonalcoholic fatty liver disease;obesity

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2019

卷：

期：

页码：

1019-1026

DOI：

10.1002/ptr.6295

基金类别：

China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018 M632962]; Ministry of Agriculture and Rural Affairs of the People's Republic of China [CARS-19]; Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2017YFD0400803]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Epigallocatechin-3-gallate (EGCG) and caffeine in tea exert anti-obesity effects and induces nonalcoholic fatty liver disease (NAFLD) amelioration. However, previous studies usually performed a high-dose EGCG administration, whereas the insecurity was arisen in recent researches. In this study, we treated obese rats with an elaborate dose-40 mg/kg EGCG, 20 mg/kg caffeine, and the coadministration of them as low dose, which were similar to the daily intake; 160 mg/kg EGCG as high dose, which was the maximum safe dose had touched the contentious edge. The results suggested that the coadministrat...

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Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats.

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