To discover the toxicity of penicillic acid(PA),apoptosis were observed by TUNEL and the gene expression of Bcl-2,Bax,Fas and FasL were measured by RT-PCR in spleen of mice exposed to PA at different dose.Results showed that more apoptotic cells were found in spleen with the increased dose of PA.At the low dose group,the expression of Bcl-2,Fas and FasL increased,Bax decreased in spleen.The expression of Bcl-2 decreased and Bax,Fas,FasL increased in spleen at middle and high dose group,indicating that mRNA expression of Bcl-2,Bax,Fas/FasL induced by penicillic ac...