The 5-weeks old KM mice were inoculated intraperitoneally with PCV2 in this experi- ment and sacrificed at 7,14,21,28,35 and 42 days post infection, spleen,inguinal lymph nodes and Peyer's patches were collected to determine PCV2 infection by PCR and the intestinal protein was extracted to detect change of SIgA and intestine related cytokines IL-2,IL-4,IL-10 and IFN-γ content. The results showed mice intestinal SIgA,IL-2 and IFN-γ levels firstly increased and then decreased and IL-4 and IL-10 was sustained a rising trend in test group with t...