MDCC-MSB-1 cells are one of the T lymphocyte proliferative tumor cell lines induced by chicken Marek's disease virus(MDV),which has been widely used as a model in the study of an- tineoplastic drugs. The aim of this review was to investigate the mechanism of regulation of MDCC-MSB-1 cell cycle arrest in G1 phase and the signal transduction pathway of MDCC-MSB-1 cell apoptosis. Understanding MDV-induced tumor cell proliferation inhibition mechanism will be help- ful to the treatment of human cancer disease research to provide a good animal m...