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Characterization of Fusarium verticillioides Med1 LxxLL Motif Involved in Fumonisin Biosynthesis

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成果类型:
期刊论文
作者:
Zhou, Zehua;Liu, Jie;Zhang, Jie;Yan, Huijuan;Yi, Tuyong;...
通讯作者:
Yi, TY;Shim, WB
作者机构:
[Liu, Jie; Yi, Tuyong; Zhou, Zehua; Yi, TY] Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Pests, Changsha 410128, Peoples R China.
[Zhang, Jie] Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Peoples R China.
[Yan, Huijuan] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA.
[Shim, Won Bo] Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX 77843 USA.
通讯机构:
[Yi, TY ] H
[Shim, WB ] T
Hunan Agr Univ, Hunan Prov Key Lab Biol & Control Plant Pests, Changsha 410128, Peoples R China.
Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX 77843 USA.
语种:
英文
关键词:
Fusarium verticillioides;Med1 LxxLL motif;carotenoids biosynthesis;fumonisin B1;starch metabolism
期刊:
TOXINS
ISSN:
2072-6651
年:
2023
卷:
15
期:
11
页码:
652-
基金类别:
Methodology, Z.Z.; software, Z.Z.; validation, Z.Z.; formal analysis, Z.Z.; investigation, Z.Z., J.L. and J.Z.; data curation, Z.Z., J.L. and J.Z.; writing-original draft preparation, Z.Z.; writing-review and editing, Z.Z., H.Y., T.Y. and W.B.S.; funding acquisition, Z.Z. All authors have read and agreed to the published version of the manuscript. This work was supported by the Natural Science Foundation of Hunan 2023JJ40326 (to Z.Z.), the Natural Science Foundation of Changsha kq2202225 (to Z.Z.), and the National Natural Science Foundation of China 32202354 (to Z.Z.).
机构署名:
本校为第一且通讯机构
院系归属:
植物保护学院
摘要:
The Med1 transcriptional coactivator is a crucial component of the Mediator middle complex, which regulates the expression of specific genes involved in cell development, differentiation, reproduction, and homeostasis. The Med1 LxxLL motif, a five-amino-acid peptide sequence, is essential for Med1-mediated gene expression. Our previous study revealed that the disruption of the Med1 subunit leads to a significant increase in fumonisin B1 (FB1) production in the maize pathogen Fusarium verticillioides. However, our understanding of how Med1 regulates FB1 biosynthesis in F. verticillioides, parti...

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