The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin

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成果类型：

期刊论文

作者：

Wu, Jing;Yang, Chenglin;Yang, Mengran;Liang, Zengenni;Wu, You;...

通讯作者：

Yi, J.;Yuan, Z.

作者机构：

[Wang, Siqi; Yi, Jine; Ning, Can; Fan, Hui; Xiao, Wenguang; Wu, You; Yuan, Zhihang; Wu, Jing; Yang, Mengran; Kong, Xiangyi; Yang, Chenglin] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Wang, Siqi; Yi, Jine; Ning, Can; Fan, Hui; Xiao, Wenguang; Wu, You; Yuan, Zhihang; Wu, Jing; Yang, Mengran; Kong, Xiangyi; Yang, Chenglin] Hunan Collaborat Innovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.

[Liang, Zengenni] Dept Hunan Agr Prod Proc Inst, Changsha 410128, Peoples R China.

[Jin, Ye] Hunan Pujian Biol Technol Co Ltd, Changsha 410128, Peoples R China.

通讯机构：

[Jine Yi] H

Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR China<&wdkj&>Hunan Collaborative Innovation Center of Animal Production Safety, Changsha 410128, PR China

语种：

英文

关键词：

Citrinin;ROS;ER stress;AMPK;Cell cycle arrest;Apoptosis

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2022

卷：

237

页码：

113531

DOI：

10.1016/j.ecoenv.2022.113531

基金类别：

This work was supported by National Natural Science Foundation of China ( 31802238 and 31572563 ), The Natural Science Foundation of Hunan Province ( 2019JJ50272 ), The Natural Science Foundation of Hunan Province ( 2021JJ30343 and 2020JJ4368 ), The Key Research and Development Program of Hunan Province ( 2020NK2032 ), Innovation Research and Development Project of Hunan Development and Reform Commission (Grant No. 37 ).

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Citrinin, a secondary metabolite, can pose serious risks to the environment and organisms, but its hepatotoxic mechanisms are still unclear. Histopathological and ultrastructural results showed that citrinin-induced liver injury in Kunming mice, and the mechanism of citrinin-induced hepatotoxicity was studied in L02 cells. Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression. Secondly, citrinin inhibits proliferation and promotes apoptosis of L0...

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The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin

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