期刊论文

Liang, Songping

英文

FASEB JOURNAL

0892-6638

2011

25

9

3177-3185

10.1096/fj.10-178848

National 973 Project of ChinaNational Basic Research Program of China [2010CB529801, 2009BC526510]; Hunan Provincial Education DepartmentHunan Provincial Education Department [07A035, 10B049]; Chinese Ministry of EducationMinistry of Education, China [208096]; Huo Ying Dong Education Foundation [111023]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-07-0279]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30900242, 3100047]; Hunan Education Department of Science and Technology [10C0961]

本校为其他机构

With conserved structural scaffold and divergent electrophysiological functions, animal toxins are considered powerful tools for investigating the basic structure-function relationship of voltage-gated sodium channels. Jingzhaotoxin-III (β-TRTX-Cj1α) is a unique sodium channel gating modifier from the tarantula Chilobrachys jingzhao, because the toxin can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes. However, the molecular basis of JZTX-III interaction with sodium channels remains unknown. In this stu...