期刊论文

Progress of SIRT3 in Regulation of Lipid Metabolism and Antioxidant Defense

中文

动物医学进展

1007-5038

2019

40

5

94-97

10.16437/j.cnki.1007-5038.2019.05.018

国家自然科学基金青年基金项目(31502135).

本校为第一机构

沉默信息调控因子2样蛋白3(SIRT3或Sirtuin3)是位于线粒体的主要去乙酰化酶,是机体脂代谢及抗氧化防御的重要调节者.SIRT3对脂肪酸β-氧化关键酶长链酰基CoA脱氢酶(LCAD)等进行脱乙酰化修饰调节脂代谢,还可活化AMPK通路调节脂代谢.SIRT3还可对抗氧化因子超氧化物歧化酶(Mn-SOD/SOD2)和异柠檬酸脱氢酶2(IDH2)的赖氨酸活化位点脱乙酰化增强抗氧化防御.论文总结SIRT3在脂代谢和抗氧化防御的调节作用,以期为揭示能量代谢障碍性疾病的发病机制提供启示,进而为探寻防治新靶标奠定理论基础.

SIRT3(silent information regulator 3 ),a major deacetylase in mitochondria,plays a pivotal role in the regulation of lipid metabolism and antioxidant defense.SIRT3 regulates lipid metabolism by deacetylation of long-chain acyl CoA dehydrogenase (LCAD) etc,key enzymes of fatty acid beta oxidation and also by activation of AMPK pathway.SIRT3 activates antioxidant key enzymes superoxide dismutase (Mn-SOD/SOD2) and isocitrate dehydrogenase 2 (IDH2) by deacetylation of to modulate antioxidant defense.This paper systematically summarized the effect of SIRT3 in the regulation of lipid metabolism and ...