MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Ming;Xiao, Yubo;Liu, Minqi;Ning, Qian;Xiang, Ziye;...

通讯作者：

Tang, S.;Mo, Z.

作者机构：

[Li, Ming; Xiao, Yubo; Tang, Shengsong; Ning, Qian] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.

[Li, Ming; Zheng, Xiang; Liu, Minqi; Mo, Zhongcheng] Guilin Med Univ, Guangxi Key Lab Mol Med Liver Injury & Repair, Guilin 541001, Guangxi, Peoples R China.

[Liu, Minqi; Mo, Zhongcheng] Guilin Med Univ, Guangxi Prov Postgrad Co Training Base Cooperat I, Yueyang 414000, Peoples R China.

[Liu, Minqi; Mo, Zhongcheng] Yueyang Women & Childrens Med Ctr, Yueyang 414000, Peoples R China.

[Xiang, Ziye] Changsha Med Univ, Sch Med Lab Sci, Changsha 410000, Peoples R China.

通讯机构：

[Shengsong Tang] H

[Zhongcheng Mo] G

Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin, China<&wdkj&>Guangxi Province Postgraduate Co-Training Base for Cooperative Innovation in Basic Medicine (Guilin Medical University and Yueyang Women & Children’s Medical Center), Yueyang, China<&wdkj&>Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua, China<&wdkj&>College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China

语种：

英文

关键词：

Cervical cancer;miR-26a-5p;HSDL2;Proliferation;Apoptosis

期刊：

BMC Cancer

ISSN：

1471-2407

年：

2022

卷：

期：

页码：

1-12

DOI：

10.1186/s12885-022-09970-x

基金类别：

This research was funded by Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System (2018TP1044), Guangxi Key Laboratory of Molecular Medicine in Live Injury and Repair, grant number (GXLIRMMKL-K202006), Promotion project for the basic scientific research ability of young and middle-aged teachers in Guangxi colleges and universities, grant number (2020KY12017), and Natural Science Foundation of Hunan Province (2021JJ30482).

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Background: Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, the influences of miR-26a-5p on proliferation, apoptosis and invasion are still vague in the cervical cancer (CC) cells. Methods: The miRNA microarray and real-time quantitative PCR (RT-qPCR) analysis were utilized to detect the expression of miR-26a-5p in the patients with CC. Kaplan–Meier plotter was performed to evaluate the overall survival (OS) of the patients with CC. The CCK-8, flow cytometry, transwell and wound heal...

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MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

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