Inhibiting effects of epigallocatechin gallate (EGCG) on the formation of age pigment in vitro and in vivo

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成果类型：

期刊论文

作者：

Cai, Shuxian;Huang, Jianan;Wang, Li-li;Dong, Xin-rong;Gong, Yu-shun;...

通讯作者：

Liu, Zhong-hua

作者机构：

[Gong, Yu-shun; Liu, Zhong-hua; Dong, Xin-rong; Li, Qing; Huang, Jianan; Li, Juan; Cai, Shuxian; Wang, Li-li] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Minist Educ Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Gong, Yu-shun; Liu, Zhong-hua; Dong, Xin-rong; Li, Qing; Huang, Jianan; Li, Juan; Cai, Shuxian; Wang, Li-li] Hunan Agr Univ, Key Lab, Minist Educ Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhong-hua; Luo, Guo-an] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.

[Liu, Zhong-hua; Luo, Guo-an] Minist Educ, Key Lab Biol Organ Phosphorus & Chem Biol, Beijing 100084, Peoples R China.

通讯机构：

[Liu, Zhong-hua] H

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Minist Educ Tea Sci, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Epigallocatechin gallate (EGCG);age pigment;galloyl group;amino-carbonyl cross-linking products

期刊：

Journal of Medicinal Plants Research

ISSN：

1996-0875

年：

2011

卷：

期：

页码：

5470-5478

DOI：

10.5897/JMPR.9000797

基金类别：

National High Tech R and D Program of China (973 Program)National Basic Research Program of ChinaNational High Technology Research and Development Program of China [2008CB117007]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31100501, 30871572]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Lipofuscin age pigment is often considered as a hallmark of aging, which shows an accumulation rate inversely correlated with longevity and it is primarily composed of carbonyl-amino cross linked protein residues. The purpose of this study is to determine whether epigallocatechin gallate (EGCG) would inhibit the formation of age pigment in both MDA-modified human serum albumin and D-galactose-induced aging mice models by using spectrofluorometry, HPLC-PDA, FTIR spectrometer, SEM and TEM observation. Results showed that EGCG could inhibit the formation of age pigment in vitro and in vivo. The s...

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Inhibiting effects of epigallocatechin gallate (EGCG) on the formation of age pigment in vitro and in vivo

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