AP2X-1 is a negative regulator of Toxoplasma gondii sexual commitment

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成果类型：

期刊论文

作者：

Sun, Li-Xiu;Wang, Meng;Zhang, Tian-Yu;Elsheikha, Hany M.;Zhang, Zhi-Wei;...

通讯作者：

Wang, JL;Liu, GH;Zhu, XQ

作者机构：

[Sun, Li-Xiu; Wang, Jin-Lei; Zhang, Tian-Yu; Zhang, Zhi-Wei; Wang, Meng; Fu, Bao-Quan] Lanzhou Vet Res Inst, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Gansu, Peoples R China.

[Sun, Li-Xiu; Zhang, Tian-Yu; Liu, Guo-Hua] Hunan Agr Univ, Coll Vet Med, Res Ctr Parasites & Vectors, Changsha, Hunan, Peoples R China.

[Elsheikha, Hany M.] Univ Nottingham, Fac Med & Hlth Sci, Sch Vet Med & Sci, Sutton Bonington Campus, Nottingham, England.

[Zheng, Xiao-Nan; Zhu, Xing-Quan] Shanxi Agr Univ, Coll Vet Med, Lab Parasit Dis, Taiyuan, Shanxi, Peoples R China.

通讯机构：

[Wang, JL ] L

[Zhu, XQ ] S

[Liu, GH ] H

Lanzhou Vet Res Inst, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Gansu, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Res Ctr Parasites & Vectors, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Toxoplasma gondii;AP2X-1;HDAC3/MORC complex;gene expression;sexual development;transcription

期刊：

MBIO

ISSN：

2161-2129

年：

2025

页码：

e0005225

DOI：

10.1128/mbio.00052-25

基金类别：

National Natural Science Foundation of China

机构署名：

本校为通讯机构

院系归属：

动物医学院

摘要：

Toxoplasma gondii is a widespread protozoan with a complex life cycle, characterized by transitions between various hosts and developmental stages, each tailored to a specific niche within its host. However, the regulatory mechanisms governing these life cycle transitions are not well understood. In this study, we investigated the AP2 factor AP2X-1, which is expressed during the tachyzoite and bradyzoite stages but decreases in the mature merozoite stage. Knockout of ap2X-1 significantly impaired tachyzoite invasion and replication while increasing the frequency of bradyzoite differentiation. ...

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AP2X-1 is a negative regulator of Toxoplasma gondii sexual commitment

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