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Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders

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成果类型:
期刊论文
作者:
Yang, Xin-hua;Wang, Yi;Huang, Jia;Zhu, Cui-ying;Liu, Xiao-qun;Cheung, Eric F. C.;Xie, Guang-rong;Chan, Raymond C. K.*
通讯作者:
Chan, Raymond C. K.
作者机构:
[Wang, Yi; Yang, Xin-hua; Chan, Raymond C. K.; Huang, Jia] Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
[Yang, Xin-hua; Zhu, Cui-ying] Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China.
[Xie, Guang-rong] Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
[Cheung, Eric F. C.] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China.
[Liu, Xiao-qun] Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.
通讯机构:
[Chan, Raymond C. K.] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
语种:
英文
关键词:
Major depressive disorder;Cortical thickness;Caudate–cortical network;Anhedonia;Parietal gyrus
期刊:
Psychiatry Research: Neuroimaging
ISSN:
0925-4927
年:
2015
卷:
234
期:
1
页码:
144-151
基金类别:
Chinese Academy of Sciences [XDB02030002]; National Science Fund China [81088001, 31100747, 81371492]; Beijing Training Project for the Leading Talents in ST [Z151100000315020]; Key Laboratory of Mental Health; China Postdoctoral Science Foundation [2015M571149]; PhD research startup foundation of Hunan Agricultural University [15RCPT04]
机构署名:
本校为其他机构
院系归属:
商学院
摘要:
Cerebral morphological abnormalities in major depressive disorder (MDD) may be modulated by antidepressant treatment and course of illness in chronic medicated patients. The present study examined cortical thickness in patients with untreated first-episode MDD to elucidate the early pathophysiology of this illness. Here, we examined cortical thickness in patients with first-episode MDD (N=27) and healthy controls (N=27) using an automated surface-based method (in FreeSurfer). By assessing the correlation between caudate volume and cortical thickness at each vertex on the cortical surface, a caudate-cortical network was obtained for each group. Subsequent analysis was performed to assess the effect of anhedonia by the Temporal Experience of Pleasure Scale. We observed increased cortical thickness at the right orbital frontal cortex and the left inferior parietal gyrus in MDD patients compared with healthy controls. Furthermore, morphometric correlational analysis using cortical thickness measurement revealed increased caudate-cortical connectivity in the bilateral superior parietal gyrus in MDD patients. All changes were not related to anhedonia. These preliminary findings may reflect disorder manifestation close to illness onset and may provide insight into the early neurobiology of MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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