期刊论文、会议论文

Li, Xumeng

英文

2010 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE

2156-1125

2010

214-217

IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

IEEE International Conference on Bioinformatics and Biomedicine-BIBM

DEC 18-21, 2010

Hong Kong, HONG KONG

[Li, Xumeng;Wang, Zijun;Luo, Feng] Clemson Univ, Sch Comp, Clemson, SC 29634 USA.^[Feltus, F. Alex] Clemson Univ, Dept Genet & Biochem, Clemson, SC 29634 USA.^[Sun, Xiaoqian] Clemson Univ, Dept Math Sci, Clemson, SC 29634 USA.^[Li, Xumeng] Hunan Agr Univ, Dept Informat & Comp Sci, Changsha, Hunan, Peoples R China.

IEEE Computer Soc, Hong Kong Univ Sci & Technol, Sch Engn, IEEE Croucher Fdn, KC wong Edu Fdn, BIBS, DNA link, Medicinal Bioconvergence Res Center of Korea

Park, T Chen, L Wong, L Tsui, S Ng, M Hu, X

345 E 47TH ST, NEW YORK, NY 10017 USA

IEEE

978-1-4244-8307-5

10.1109/BIBM.2010.5706565

Institute for Modeling and Simulation Applications at Clemson University; NSFNational Science Foundation (NSF) [0960586]

本校为其他机构

Identification of genes and pathways involving in diseases and physiological conditions is a major task in systems biology. In this study, we develop a new non-parameter Ising model to integrate protein-protein interaction network and microarray data for identifying differentially expressed (DE) genes. We also propose a simulated annealing algorithm to find the optimal configuration of the Ising model. We test the Ising model to two breast cancer microarray data sets. The results show that more cancer related differentially expressed sub-networ...