Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs

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成果类型：

期刊论文

作者：

Liu, Lei;Yi, Guoqiang*;Yao, Yilong;Liu, Yuwen;Li, Jiang;...

通讯作者：

Yi, Guoqiang;Tang, ZL;Groenen, MAM

作者机构：

[Zhang, Yongsheng; Fan, Xinhao; Tang, Zhonglin; Wang, Zhen; Li, Xingzheng; Yi, Guoqiang; Qu, Xiaolu; Liu, Yuwen; Yang, Yalan; Yuan, Pengxiang; Li, Kui; Liu, Lei; Yao, Yilong; Chen, Muya; Yi, GQ; Wang, Liyuan; Tang, Yijie; Wang, Lei; Chen, Yun] Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch,Key Lab Livestock & Poultry Multio, Shenzhen 518124, Peoples R China.

[Fan, Xinhao; Yi, Guoqiang; Liu, Yuwen; Yang, Yalan; Liu, Lei; Yao, Yilong; Tang, Zhonglin] Chinese Acad Agr Sci, Agr Genom Inst, Kunpeng Inst Modern Agr Foshan, Foshan, Peoples R China.

[Liu, Lei] Yazhouwan Natl Lab, Sanya, Peoples R China.

[Yi, Guoqiang; Liu, Yuwen; Tang, Zhonglin] GuangXi Engn Ctr Resource Dev Bama Xiang Pig, Bama, Peoples R China.

[Niu, Yongchao; Li, Jiang] Biozeron Shenzhen Inc, Shenzhen, Peoples R China.

通讯机构：

[Yi, GQ; Tang, ZL ] C

[Groenen, MAM ] W

Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch,Key Lab Livestock & Poultry Multio, Shenzhen 518124, Peoples R China.

Wageningen Univ & Res, Anim Breeding & Genom Grp, POB 338, NL-6700 AH Wageningen, Netherlands.

语种：

英文

关键词：

epigenetics;genomic variation;pan-genome;phenotype differentiation;pig;skeletal muscle development

期刊：

iMeta

ISSN：

2770-5986

年：

2024

卷：

期：

页码：

e250

DOI：

10.1002/imt2.250

基金类别：

National Key Scientific Research Project; National Natural Science Foundation of China [U23A20229, 32002150, 32002151]; Agricultural Science and Technology Innovation Program [CAAS-ZDRW202406]; [2023YFF1001100]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

By combining nine high‐quality pig genomes and 1081 resequencing data sets, researchers constructed a comprehensive pan‐genome and genetic variation data set for pigs, laying the groundwork for analyzing complex traits. This data set identified selective sweep signals and genes related to fat deposition, muscle growth, and immune function, providing genetic markers for breeding. Integration of transcriptome and methylome data from 27 muscle development stages revealed epigenetic mechanisms behind muscle growth differences between Eastern and ...

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Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs

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