Identification of novel α-glucosidase and ACE inhibitory peptides from Douchi using peptidomics approach and molecular docking

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成果类型：

期刊论文

作者：

Guo, Weidan;Xiao, Yu;Fu, Xiangjin;Long, Zhao;Wu, Yue;...

通讯作者：

Fu, XJ

作者机构：

[Guo, Weidan; Xiao, Yu; Long, Zhao; Wu, Yue; Fu, Xiangjin; Fu, XJ; Lin, Qinlu; Ren, Kangzi] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

[Fu, Xiangjin; Fu, XJ; Lin, Qinlu] Nutr & Hlth Prod Engn Technol Res Ctr Hunan Prov, Changsha 410004, Peoples R China.

[Long, Zhao; Fu, Xiangjin; Fu, XJ; Lin, Qinlu] Hunan Prov Engn Technol Res Ctr Seasonings Green M, Changsha 410004, Peoples R China.

[Long, Zhao; Wu, Yue; Fu, Xiangjin; Fu, XJ; Lin, Qinlu] Cent South Univ Forestry & Technol, Key Lab Special Med Food Proc Hunan Prov, Changsha 410004, Peoples R China.

[Jiang, Liwen] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.

通讯机构：

[Fu, XJ ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

Nutr & Hlth Prod Engn Technol Res Ctr Hunan Prov, Changsha 410004, Peoples R China.

Hunan Prov Engn Technol Res Ctr Seasonings Green M, Changsha 410004, Peoples R China.

Cent South Univ Forestry & Technol, Key Lab Special Med Food Proc Hunan Prov, Changsha 410004, Peoples R China.

语种：

英文

关键词：

ACE;Douchi;Molecular docking;Peptidomics;α-glucosidase

期刊：

Food Chemistry: X

ISSN：

2590-1575

年：

2023

卷：

页码：

100779

DOI：

10.1016/j.fochx.2023.100779

基金类别：

Thanks the support of the National Key Research and Development Program of China (No. 2022YFD2101303). Peptidomics analysis was assisted by Biotree Biotech Co. Ltd (Shanghai, China).

机构署名：

本校为其他机构

院系归属：

食品科学技术学院

摘要：

In this study, the effect of Douchi extract (DWE) on α-glucosidase and angiotensin-converting enzymes (ACE) were investigated, and several novel peptides with inhibitory activity against α-glucosidase and ACE were identified using peptidomics approach based on UPLC-MS/MS. The average inhibition rates of DWE on α-glucosidase and ACE were 73.75–78.10% and 4.56–27.07%, respectively. In the DWE, a total of 710 peptides were detected. Two novel peptides with potential inhibitory activity against α-glucosidase were identified using the correlat...

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Identification of novel α-glucosidase and ACE inhibitory peptides from Douchi using peptidomics approach and molecular docking

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